Britain approves the creation of ‘three-parent’ babies
New IVF treatment is designed to help families with mitochondrial diseases
Scientists use a pipette to remove the nucleus from an egg. British authorities have approved a controversial techniques allowing doctors to create babies using DNA from three people. Photograph: OHSU Centre for Embryonic Cell and Gene Therapy/AP
Britain on Thursday became the first country to formally license an in-vitro fertilisation (IVF) treatment designed to create babies from three people.
Critics of the treatment say it is a dangerous step that will lead to the creation of genetically modified “designer babies”.
In a long-awaited decision, Britain’s Human Fertilisation and Embryology Authority (HFEA) gave the final go-ahead for the treatment, known as mitochondrial transfer, which doctors say could help prevent incurable inherited diseases.
Britain’s parliament voted last year to change the law to allow the treatments if and when they were ready for licensing.
This latest HFEA decision means the first babies created by the technique in Britain could be born in 2017.
The government’s chief scientific adviser, Mark Walport, praised the HFEA’S decision as a “careful and considered” assessment which put Britain at the forefront of medical advances.
The technique involves intervening in the fertilisation process to remove mitochondria, which act as tiny energy-generating batteries inside cells, and which, if faulty, can cause fatal heart problems, liver failure, brain disorders, blindness and muscular dystrophy.
The treatment is designed to help families with mitochondrial diseases - incurable conditions passed down the maternal line that affect about one in 6,500 children worldwide.
“Mitochondrial donation offers a real opportunity to cure a class of potentially devastating inherited conditions and will bring hope to hundreds of affected families in the UK,” said Dagan Wells, a professor at Oxford University’s biomedical research centre and one of many experts welcoming the decision.
The treatment is known as “three-parent” IVF because the babies, born from genetically modified embryos, would have DNA from a mother, a father and from a female donor.
Jeremy Farrar, director of the Wellcome Trust global health charity, said it was a “landmark day for people living with mitochondrial disease”.
Research teams across the world have tested and trialled the techniques in a series of pre-clinical experiments, but as yet they have not been used to treat patients in Britain.
The world’s first and so-far only known mitochondrial transfer baby was born earlier this year, after US doctors working at a clinic in Mexico helped a Jordanian couple conceive using the new three-way treatment.
“This decision opens the door to the world of GM designer babies,” he said, in an emailed statement.