SATURDAY Arsenal (4) v Tottenham (9)
Arsenal expect to have midfielder Mathieu Flamini back from a dead leg. Defenders Kieran Gibbs and Per Mertesacker should also be available after being kept on the bench for what was a much-changed squad in the midweek Capital One Cup defeat to Southampton. Spain defender Nacho Monreal (back) remains out, as does striker Yaya Sanogo (hamstring). Winger Theo Walcott (knee) continues his recovery along with midfielder Serge Gnabry (knee), but full back Mathieu Debuchy (ankle) and France forward Olivier Giroud (fractured foot) are long-term absentees.
Mauricio Pochettino has no fresh injury concerns. The Tottenham head coach made 11 changes for Wednesday's Capital One Cup win over Nottingham Forest and is expected to make wholesale alterations for the trip to the Emirates Stadium. Ex-Arsenal man Emmanuel Adebayor, Christian Eriksen, Erik Lamela and Nacer Chadli are all likely to be recalled to the Spurs attacking line, with Kyle Walker the only significant absentee from Pochettino's squad following abdominal surgery.
Last season: Tottenham 0 Arsenal 1, Arsenal 1 Tottenham 0
Last five league matches: Arsenal W D D D W; Tottenham W W L D L
Top scorers (all competitions): Alexis Sanchez (Arsenal) 4; Harry Kane & Nacer Chadli (Tottenham) 3
Match odds: H 8-11 A 7-2 D 14-5
Referee: Michael Oliver
Chelsea (1) v Aston Villa (3)
Diego Costa is to return to Chelsea's starting line-up despite his hamstring travails. Striker Costa, who has scored seven Premier League goals this season, was rested for the midweek Capital One Cup defeat of Bolton, in which Chelsea made nine changes from the side which began the draw at Manchester City. Manager Jose Mourinho is likely to revert to the majority of the side which started at City, although Brazil midfielder Ramires (abductor muscle) is out for at least another week.
Aston Villa hope to be close to full strength after a virus hit the squad last weekend. A number of players were affected by a bug before, during and after their 3-0 Premier League defeat by Arsenal. However, manager Paul Lambert believes the illness has cleared up and only captain Ron Vlaar (calf) and strikers Christian Benteke (Achilles) and Libor Kozak (broken leg) are unavailable.
Last season: Aston Villa 1 Chelsea 0, Chelsea 2 Aston Villa 1
Last five league matches: Chelsea W W W W D; Aston Villa W D W W L
Top scorers (all competitions): Diego Costa (Chelsea) 7; Gabriel Agbonlahor & Andreas Weimann (Aston Villa) 2
Match odds: H 2-9 A 12-1 D 5-1
Referee: Phil Dowd
Crystal Palace (15) v Leicester (7)
Marouane Chamakh is available again for Palace after the Morocco striker missed Saturday's 3-2 Premier League win at Everton and the Capital One Cup loss to Newcastle with hamstring trouble. Manager Neil Warnock reported no further injury problems following the midweek extra-time loss to the Magpies.
Leicester manager Nigel Pearson has no fresh injury concerns. Defender Matthew Upson remains the only absentee with an ongoing calf issue, although Pearson has confirmed Zoumana Bakayogo – not listed in the squad at the start of the season – is to undergo surgery on an anterior cruciate ligament injury. On-loan striker Nick Powell is available again after missing last week's 5-3 win over parent club Manchester United due to ineligibility.
Last season: No corresponding fixture
Last five league matches: Crystal Palace L L D D W; Leicester D L D W W
Top scorers (all competitions): Dwight Gayle (Crystal Palace) 5; Leonardo Ulloa (Leicester) 5
Match odds: H 13-8 A 17-10 D 9-4
Referee: Keith Stroud
Hull (10) v Manchester City (6)
Hull manager Steve Bruce will continue to ease Hatem Ben Arfa in slowly with a place on the bench. The loan star made his first Tigers start in the Capital One Cup defeat at West Brom but is not yet considered fully fit by Bruce. Fellow new boy Gaston Ramirez is likely to sit out with a groin complaint, David Meyler took a knock in midweek and Robert Snodgrass (knee) is a long-term absentee.
Manchester City have Sergio Aguero and David Silva back available. Aguero and Silva are set to return after missing the midweek Capital One Cup victory over Sheffield Wednesday due to knee and ankle problems respectively, along with Pablo Zabaleta, who sat out the tie as he served a one-match suspension. Samir Nasri, Fernando (both groin) and Stevan Jovetic (hamstring) remain sidelined.
Last season: Hull 0 Man City 2, Man City 2 Hull 0
Last five league matches: Hull W D L D D; Man City W W L D D
Top scorers (all competitions): Nikica Jelavic & Robbie Brady (Hull) 3; Sergio Aguero & Frank Lampard (Man City) 3
Match odds: H 9-2 A 4-7 D 3-1
Referee: Anthony Taylor
Liverpool (11) v Everton (14)
Liverpool remain hopeful striker Daniel Sturridge could return for the Merseyside derby. Sturridge suffered a thigh injury on England duty earlier this month and will be given every chance to prove his fitness. Midfielder Jordan Henderson (hip) and playmaker Philippe Coutinho (groin) are among a number of other players who could return.
Everton duo Seamus Coleman and Steven Pienaar are facing a race to be fit for the Merseyside derby. Full back Coleman has missed the last two games with a head injury while midfielder Pienaar damaged a thigh in Everton's second game of the season. Midfielder Darron Gibson and full back Bryan Oviedo have both proved their fitness after long-term injuries but striker Arouna Kone needs some minutes on the pitch and playmaker Ross Barkley (knee) is still several weeks away.
Last season: Liverpool 4 Everton 0, Everton 3 Liverpool 3
Last five league matches: Liverpool W L W L L; Everton D D L W L
Top scorers (all competitions): Raheem Sterling (Liverpool) 3; Kevin Mirallas & Steven Naismith (Everton) 3
Match odds: H 4-5 A 16-5 D 11-4
Referee: Martin Atkinson
Manchester United (12) v West Ham (8)
Teenage Northern Ireland defender Paddy McNair could make his first-team debut after Louis van Gaal's Manchester United squad was decimated by injury. Tyler Blackett (suspended), Jonny Evans (ankle), Chris Smalling (thigh) and Phil Jones (hamstring) are all out, which leaves Marcos Rojo as Van Gaal's only fit senior centre half. Left back Luke Shaw is expected to make his debut, but midfielders Ashley Young (groin), Michael Carrick (ankle), Jesse Lingard (knee) and Marouane Fellaini (ankle) are unavailable.
West Ham will be without midfielder Cheikhou Kouyate. The Senegal international has been ruled out with a groin injury suffered in the 3-1 win over Liverpool and could be missing for up to six weeks. Captain Kevin Nolan is back in training following a fractured shoulder but will not be considered at Old Trafford, whilst Matt Jarvis (thigh) is in a similar position. Joey O'Brien (knee) and Andy Carroll (ankle) are also missing but James Collins is in contention to start after coming off the bench last weekend.
Last season: West Ham 0 Man Utd 2, Man Utd 3 West Ham 1
Last five league matches: Man Utd L D D W L; West Ham L W L D W
Top scorers (all competitions): Juan Mata, Ander Herrera, Wayne Rooney & Angel di Maria (Man Utd) 2; Diafra Sakho (West Ham) 3
Match odds: H 1-3 A 8-1 D 4-1
Referee: Lee Mason
Southampton (2) v QPR (18)
Southampton defenders Toby Alderweireld and Maya Yoshida's respective hamstring and ankle complaints will be assessed and they are both doubts. James Ward-Prowse has been ruled out for up to 12 weeks with a fractured foot, while Sadio Mane could make his Premier League debut after impressing in Tuesday's Capital One Cup win at Arsenal.
Sandro's knee injury is less serious than first feared but the QPR midfielder is unlikely to return at St Mary's. The Brazilian appeared to injure his knee while celebrating a goal in training and was absent for last weekend's 2-2 draw against Stoke. Joey Barton and Jordon Mutch are both out with hamstring injuries while Niko Kranjcar is doubtful after picking up a knock against Stoke. Adel Taarabt has a sore ankle and is also unavailable.
Last season: No corresponding fixture
Last five league matches: Southampton L D W W W; QPR L L W L D
Top scorers (all competitions): Graziano Pelle (Southampton) 4; Charlie Austin, Niko Kranjcar & Steven Caulker (QPR) 1
Match odds: H 4-9 A 13-2 D 10-3
Referee: Mark Clattenburg
Sunderland (17) v Swansea (5)
Sunderland head coach Gus Poyet will make late decisions on a trio of key players. Defender Wes Brown and striker Steven Fletcher both missed Tuesday night's Capital One Cup defeat by Stoke with calf problems, while midfielder Emanuele Giaccherini sat out with an ankle injury, and all three are being assessed. But Poyet has indicated he will make changes with full back Billy Jones and winger Will Buckley confirmed as starters with the Black Cats still looking for a first league win of the campaign.
Wilfried Bony will return for Swansea after serving a one-match ban. Bony was sent off in the 1-0 home defeat to Southampton last weekend but served his ban in the Capital One Cup in midweek as Swansea swept aside Everton 3-0 to reach the last 16. Swansea boss Garry Monk has no new injury worries ahead of visiting the Stadium of Light, but defender Jordi Amat (knee) and midfielder Leon Britton (knee) are still absent.
Last season: Sunderland 1 Swansea 3, Swansea 4 Sunderland 0
Last five league matches: Sunderland D D L D D; Swansea W W W L L
Top scorers (all competitions): Adam Johnson (Sunderland) 2; Nathan Dyer (Swansea) 4
Match odds: H 13-8 A 17-10 D 9-4
Referee: Chris Foy
West Brom (16) v Burnley (19)
West Brom are sweating on the fitness of strikers Brown Ideye and Victor Anichebe. Ideye injured his ankle scoring his first goal for the club in Wednesday's 3-2 Capital One Cup victory over Hull while Anichebe is struggling after a hernia operation. Saido Berahino, who scored the winner against Hull, and Georgios Samaras are primed to start up front after coming on in midweek. Chris Baird is still suffering from the illness which kept him out against the Tigers and is likely to sit out the game.
Burnley will run the rule over Kieran Trippier, David Jones and Dean Marney. Full back Trippier has a minor groin complaint while the central midfield pair of Jones (thigh) and Marney (hamstring) have also been struggling with slight problems this week. Strikers Danny Ings (hamstring) and Sam Vokes (knee) remain absent while utility man Matt Taylor has an ongoing Achilles concern which will keep him sidelined.
Last season: No corresponding fixture
Last five league matches: West Brom D D L L W; Burnley L L D D D
Top scorers (all competitions): Saido Berahino (West Brom) 3 Scott Arfield (Burnley) 1
Match odds: H 1-1 A 3-1 D 9-4
Referee: Jon Moss
Stoke (13) v Newcastle (20)
Stoke manager Mark Hughes has virtually a full squad to choose from. Midfielder Jonathan Walters is the only doubt as he will undergo a late fitness test on a calf problem that has sidelined him for the last two weeks. The game comes too soon for defender Geoff Cameron (hernia) who is nearing a return, whilst striker Peter Odemwingie (knee) is a long-term casualty.
Newcastle boss Alan Pardew will hope to restore big guns Tim Krul, Yoan Gouffran and Papiss Cisse to his starting line-up. The trio missed the Capital One Cup third-round victory at Crystal Palace in midweek because of illness and could return, while Pardew will keep his fingers crossed over full back Daryl Janmaat, who suffered a muscle strain at Selhurst Park. However, midfielder Mehdi Abeid is suspended after being sent off at Palace, while defender Davide Santon (knee) and midfielders Siem de Jong (thigh) and Rolando Aarons (hamstring) are still out.
Last season: Stoke 1 Newcastle 0, Newcastle 5 Stoke 1
Last five league matches: Stoke L D W L D; Newcastle L D D L D
Top scorers (all competitions): Jonathan Walters, Peter Crouch, Marc Muniesa & Mame Diouf (Stoke) 2; Emmanuel Riviere & Papiss Cisse (Newcastle) 2
Match odds: H 11-10 A 13-5 D 9-4
Referee: Craig Pawson