Sinn Féin's Darren O'Rourke topped the poll in Meath East, while Minister for Social Protection Regina Doherty lost her seat and came fifth in the three-seat constituency.
Fine Gael's Helen McEntee took the second seat after winning 18 per cent of first preference votes, followed by Fianna Fáil's Thomas Byrne at 14 per cent.
They were both elected on the seventh count, with Byrne being elected without meeting the quota.
O’Rourke, who secured 24 per cent of the vote, was elected on the second count. As popularity for Sinn Féin surged over the course of the election campaign, there were fears for Doherty, who was only just ahead of O’Rourke when she claimed the last seat in the 2016 election.
However, it was unexpected that first time Green Party candidate Seán McCabe would also poll higher than the outgoing Fine Gael TD and knock her back to fifth place.
The results will leave Fine GAel disappointed as they now hold only one seat in Meath East.
O'Rourke, who has represented the Ashbourne area in Meath County Council since 2014, said his party was "quietly confident" in the lead up to the election that Sinn Féin would get a seat in this constituency.
“That, in and of itself is an achievement because we have never done that before. It’s the first time there has ever been a Sinn Féin TD in Meath-East and it’s going to be the same in a lot of places,” O’Rourke said.
“Given the stature of the three sitting TDs, it was a competitive constituency but the extent of the move towards Sinn Féin has really been extraordinary.”
Candidates: Regina Doherty (FG), Helen McEntee (FG), Thomas Byrne (FF), Deirdre Geraghty-Smith (FF), Darren O'Rourke (SF), Annie Hoey (Labour), Seán McCabe (GP), Emer Tóibín (Aontú), Sharon Keogan (Ind), Joe Bonner (Ind), Andrew Keegan (S-PBP), Seamus McDonagh (The Workers' Party).