Drug touted by Trump increases death risk in Covid-19 patients, global study finds

Hydroxychloroquine should not yet be used as coronavirus treatment, authors say

Hydroxychloroquine has been tied to dangerous heart rhythm problems. Photograph: George Frey/AFP via Getty

Hydroxychloroquine has been tied to dangerous heart rhythm problems. Photograph: George Frey/AFP via Getty

 

The malaria drug hydroxychloroquine, which US president Donald Trump says he has been taking and has urged others to use, was tied to increased risk of death in hospitalised Covid-19 patients, according to a large study published in the medical journal Lancet.

In the study that looked at over 96,000 people hospitalised with Covid-19, those treated with hydroxychloroquine or the related chloroquine had higher risk of death than patients who were not given the medicines.

The authors said they could not confirm if taking the drug resulted in any benefit in coronavirus patients.

“Urgent confirmation from randomized clinical trials is needed,” they wrote. This study was not a placebo-controlled trial.

Demand for decades-old hydroxychloroquine has surged as Mr Trump repeatedly pushed for its use against the coronavirus, urging people to try it. “What have you got to lose,” he said.

This week, Mr Trump said he has been taking hydroxychloroquine as a preventative medicine, despite a lack of scientific evidence.

The Lancet study authors suggested the medicines should not be used to treat Covid-19 outside of clinical trials until those studies confirm their safety and efficacy for Covid-19 patients.

The US Food and Drug Administration has said hydroxychloroquine should only be used for hospitalised Covid-19 patients or those in clinical trials. The drug has been tied to dangerous heart rhythm problems.

The Lancet study looked at data from 671 hospitals, where 14,888 patients were given either hydroxychloroquine or chloroquine, with or without the antibiotic macrolide, and 81,144 patients who were not treated with those drugs. – Reuters