Arsenal v Hull, 12.30pm – Live BT Sport 2
Danny Welbeck could get his first start since April and defender Laurent Koscielny faces a fitness test on a dead leg but should be fit. David Ospina will replace Petr Cech in goal while Mohamed Elneny is also poised to start. Jack Wilshere, Santi Cazorla, Tomas Rosicky and Gabriel are all out.
Hull boss Steve Bruce boss is planning to make a number of changes, with on-loan Nick Powell set to make his debut. Bruce has no fresh injury concerns to contend with but Isaac Hayden and Chuba Akpom are unable to face their parent club due to FA rules.
Top scorers (all competitions): Olivier Giroud (Arsenal) 18; Abel Hernandez (Hull) 17
Match odds: H 1-2 A 5-1 D 11-4
Referee: Mike Dean
Reading v West Brom, 3.0pm - Live Setanta Sports 1
Reading could have striker Matej Vydra fit after a hamstring injury – he was expected to be back in full training at the end of this week. Midfielder Danny Williams remains a doubt because of his hamstring injury and forward Yann Kermorgant and midfielder George Evans are cup-tied.
West Brom defender Gareth McAuley will miss out with a hamstring injury. James Morrison (hamstring) and Callum McManaman (ankle) are also out but on-loan Tottenham midfielder Alex Pritchard can play.
Top scorers (all competitions): Matej Vydra (Reading) 8; Saido Berahino, Salomon Rondon (West Brom) 6
Match odds: H 8-5 A 17-10 D 2-1
Referee: Anthony Taylor
Watford v Leeds, 3.0pm - Live Setanta Ireland
Miguel Britos (dead leg) and Jose Manuel Jurado (calf) are battling for fitness after joining training on Thursday. Costel Pantilimon, who has been Watford's chosen FA Cup goalkeeper so far in the competition, is expected to play ahead of Heurelho Gomes.
Striker Chris Wood (hamstring) remains a major doubt for Leeds but Swiss defender Gaetano Berardi (ankle) could return to contention after a two-month lay-off.
Top scorers (all competitions): Odion Ighalo (Watford) 15; Chris Wood (Leeds) 8
Match odds: H 8-13 A 4-1 D 13-5
Referee: Michael Oliver
Bournemouth v Everton, 5.15pm - Live BBC 1
Manager Eddie Howe confirmed he would be making changes but is leaving his selection "as a surprise" – although long-term absentees Max Gradel, Tyrone Mings and Callum Wilson (all knee) are still a long way from returning.
Defender John Stones is fit for Everton after a hamstring complaint. New signing Oumar Niasse is likely to have to wait for his debut as he is recovering from minor wrist surgery, while midfielder Muhamed Besic (hamstring) is out.
Top scorers (all competitions): Benik Afobe (Bournemouth) 13; Romelu Lukaku (Everton) 20
Match odds: H 21-10 A 23-20 D 23-10
Referee: Martin Atkinson
Blackburn v West Ham, 2.0pm - Live BT Sport 2
Rovers boss Paul Lambert must make changes, with Danny Graham and Matt Grimes cup-tied. Hope Akpan is a doubt after missing the win over Fulham through illness, while Danny Guthrie (hamstring), Lee Williamson (calf), Jason Lowe (foot) and Nathan Delfouneso (knee) remain sidelined.
West Ham's Andy Carroll (adductor) and Enner Valencia (ankle) have joined Diafra Sakho (thigh) on the sidelines, meaning Emmanuel Emenike is the only fit striker. With James Tomkins (calf) and Joey O'Brien (hamstring) injured and Sam Byram cup-tied, winger Michail Antonio may fill in at right back. However, midfielder Manuel Lanzini is fit after a hamstring injury.
Top scorers (all competitions): Tony Watt (Blackburn) 6; Michail Antonio (West Ham) 8
Match odds: H 12-5 A 21-20 D 9-4
Referee: Jon Moss (W Yorkshire)
Tottenham v Crystal Palace , 3.0pm – Live Setanta Ireland
Tottenham head coach Mauricio Pochettino is likely to again shuffle his pack. Captain Hugo Lloris (shoulder) will miss out, with Michel Vorm again expected to deputise in goal, while Clinton Njie and Jan Vertonghen (both knee) are also absent.
Yannick Bolasie is expected to return for Palace after a hip injury and manager Alan Pardew's options could be further strengthened by the returns of Dwight Gayle and Joe Ledley. James McArthur and Jason Puncheon miss out due to ankle and hamstring injuries respectively, while Martin Kelly is set to replace the suspended Pape Souare.
Top scorers (all competitions): Harry Kane (Tottenham) 19; Yohan Cabaye, Scott Dann, Wilfried Zaha (Crystal Palace) 5
Match odds: H 13-20 A 4-1 D 5-2
Referee: Craig Pawson
Chelsea v Man City, 4.0pm - Live BBC 1
Chelsea captain John Terry (hamstring) is out but Oscar could start, perhaps at the expense of Eden Hazard. Midfielder Nemanja Matic is available after his European suspension but Alexandre Pato is still short of match fitness and Kurt Zouma (knee) and Radamel Falcao (thigh) are long-term absentees.
City boss Manuel Pellegrini looks set to play a weakened, youthful-looking side at the start of a week that also includes a Champions League trip to Dynamo Kiev and the Capital One Cup final at Wembley. Defenders Bacary Sagna and Eliaquim Mangala, midfielders Samir Nasri, Kevin De Bruyne, Fabian Delph and Jesus Navas, and striker Wilfried Bony are all sidelined.
Top scorers (all competitions): Diego Costa (Chelsea) 12; Sergio Aguero (Man City) 18
Match odds: H 1-1 A 12-5 D 12-5
Referee: Andre Marriner
Shrewsbury v Man Utd, 7.45pm - Live BT Sport 2
Shrewsbury hope Jack Grimmer will be available – the defender is nursing a hamstring injury. Former United trainee Ritchie Wellens is cup-tied and although James Wesolowski is close to a return from a cruciate knee ligament injury, he is unlikely to be risked yet.
Goalkeeper David de Gea was set for a scan on a knee injury on Friday. United have also lost Wayne Rooney (knee), Marouane Fellaini (muscle injury), Cameron Borthwick-Jackson (illness) and Matteo Darmian (shoulder) in the last few days, while defender Donald Love is cup-tied.
Top scorers (all competitions): Andy Mangan (Shrewsbury) 11; Wayne Rooney (Man Utd) 14
Match odds: H 8-1 A 2-7 D 4-1
Referee: Robert Madley