Hull (18) v Newcastle (11), 12.45pm - Live BT Sports 1
Hull should welcome back strikers Nikica Jelavic and Abel Hernandez. The duo were both forced off in the early exchanges of the FA Cup defeat to Arsenal at the beginning of the month with knee and groin injuries respectively. A warm weather break in Portugal has also proved restorative for the Tigers' back line with Andy Robertson and Alex Bruce now available for selection, but Liam Rosenior (hamstring) and James Chester (shoulder) remain on the sidelines.
Newcastle head coach John Carver hopes to have top scorer Papiss Cisse available at the KC Stadium. The Magpies were hoping to rush the striker back from the African Nations Cup, where his nation Senegal were eliminated in the group stages. Gabriel Obertan and Mehdi Abeid should be fit to return from thigh and toe problems respectively, but the game is likely to come too soon for Dutchman Siem de Jong.
Last season: Hull 1 Newcastle 4, Newcastle 2 Hull 3
Last five league matches: Hull W L W L L; Newcastle L W D L L
Top scorers (all competitions): Nikica Jelavic (Hull) 6; Papiss Cisse (Newcastle) 9
Match odds: A 6-4 A 15-8 D 11-5
Referee: Phil Dowd
Crystal Palace (13) v Everton (12), 3.0pm
Crystal Palace midfielder Jordon Mutch is set to make his debut after joining the Eagles from QPR. Mutch is fit and ready to play against the Toffees but fellow new signing Shola Ameobi will need longer to regain match fitness after leaving Turkish side Gaziantepspor in December. Palace winger Jerome Thomas has suffered a minor knock and will be unavailable while Yannick Bolasie and Mile Jedinak are still away on international duty with DR Congo and Australia respectively.
Everton are hoping to have midfielders James McCarthy (hamstring) and Darron Gibson (knee), and defender Sylvain Distin (groin) back in contention. Winger Kevin Mirallas is expected to be fit after being substituted with a hamstring injury soon after controversially missing a penalty in the goalless draw against West Brom last time out. Goalkeeper Tim Howard (leg) and midfielders Leon Osman (foot) and Steven Pienaar (knee) remain on the sidelines.
Last season: Everton 2 Crystal Palace 3, Crystal Palace 0 Everton 0
Last five league matches: Crystal Palace L D D W W; Everton L L L D D
Top scorers (all competitions): Dwight Gayle (Crystal Palace) 10; Romelu Lukaku (Everton) 9
Match odds: H 19-10 A 6-4 D 11-5
Referee: Roger East
Liverpool (8) v West Ham (7), 3.0pm
Striker Daniel Sturridge is likely to make his first appearance in five months. Sturridge, who has not played for the Reds since August due to thigh problems, is in "top-class condition" according to manager Brendan Rodgers, who will decide on Friday whether to start the England forward or put him on the bench. Liverpool will also assess defender Mamadou Sakho, who suffered a back injury in the Capital One Cup semi-final defeat to Chelsea on Tuesday.
West Ham could be without a host of first-team regulars, with Carl Jenkinson, James Tomkins and Alex Song all suffering with unspecified problems. Joey O'Brien (hamstring) and James Collins (groin) could add to manager Sam Allardyce's defensive woes but Senegal's exit from the African Nations Cup may see Cheikhou Kouyate return in midfield.
Last season: West Ham 1 Liverpool 2, Liverpool 4 West Ham 1
Last five league matches: Liverpool W W D W W; West Ham L L D D W
Top scorers (all competitions): Steven Gerrard (Liverpool) 9; Diafra Sakho (West Ham) 10
Match odds: A 4-6 A 4-1 D 14-5
Referee: Andre Marriner
Manchester United (4) v Leicester (20), 3.0pm
Midfielder Michael Carrick has been ruled out for at least four weeks with a muscle injury. Wing back Ashley Young is closing in on a return from a hamstring injury, but midfielder Darren Fletcher has been omitted from the squad as his transfer to West Ham neared completion. Defenders Jonny Evans and Chris Smalling could return after missing the 0-0 draw against Cambridge due to unspecified injuries.
Matt Upson could make his first appearance in the Leicester squad after being sidelined since July with a foot injury. Kasper Schmeichel is still out with his broken foot but is on course in his recovery while Chris Wood is unavailable because of ankle ligament damage. Matty James is banned after his sending-off in the 1-0 win over Aston Villa earlier this month and Riyad Mahrez remains on African Nations Cup duty with Algeria.
Last season: No corresponding fixture
Last five league matches: Man Utd W D D L W; Leicester L W D W L
Top scorers (all competitions): Robin van Persie & Wayne Rooney (Man Utd) 8; Leonardo Ulloa (Leicester) 9
Match odds: A 1-3 A 8-1 D 4-1
Referee: Martin Atkinson
Stoke (10) v QPR (19), 3.0pm
Stoke will be without Bojan Krkic but look set to have fellow forward Mame Biram Diouf back in their matchday squad. In the same week as Bojan was ruled out for the rest of the season by the serious knee injury he sustained in Monday's FA Cup game at Rochdale, Diouf has returned to the Potters from African Nations Cup duty with Senegal and trained with his club-mates. Defender Erik Pieters remains unavailable as he recovers from a hernia operation.
QPR manager Harry Redknapp is expected to have both Yun Suk-young and Richard Dunne available again. Yun has been out with an ankle injury and has not played since December 20th while Dunne came off against Manchester United with a groin strain two weeks ago, but has recovered. The match will come too soon for Sandro, who is close to returning from a knee problem, and Alejandro Faurlin remains out with a cruciate ligament injury.
Last season: No corresponding fixture
Last five league matches: Stoke W W D L W; QPR L D D L L
Top scorers (all competitions): Jonathan Walters (Stoke) 7; Charlie Austin (QPR) 13
Match odds: H 8-13 A 5-1 D 13-5
Referee: Mike Dean
Sunderland (16) v Burnley (17), 3.0pm - Live Setanta Sports 1
Lee Cattermole will be missing once again as Sunderland attempt to boost their own chances of safety by denting those of Burnley. Cattermole, who has been struggling with groin and knee injuries in recent weeks, is still not fit and will be joined on the sidelines by fellow midfielder Jack Rodwell, who is suspended following his sending-off in the 0-0 FA Cup fourth round draw with Fulham last weekend. However, defender Wes Brown (knee) and winger Adam Johnson (calf) will return to the squad after sitting out against the Londoners.
Burnley have no new injury worries. Matt Taylor was unable to take part in a development game this week as he continues his recovery from Achilles surgery but boss Sean Dyche is confident he remains on track for an imminent comeback. Stephen Ward (ankle) is making good progress and is also not far away from returning, leaving defender Kevin Long (knee) as the only long-term absentee.
Last season: No corresponding fixture
Last five league matches: Sunderland L D L L L; Burnley L D D W L
Top scorers (all competitions): Adam Johnson (Sunderland) 5; Danny Ings (Burnley) 7
Match odds: H 21-20 A 14-5 D 9-4
Referee: Lee Mason
West Brom (14) v Tottenham (6), 3.0pm
New signing Callum McManaman goes straight into the squad for West Brom following his arrival from Wigan this week. Goalkeeper Boaz Myhill damaged his finger in last weekend's FA Cup win at Birmingham and is now out along with midfielder Youssouf Mulumbu (international duty) and defender Jonas Olsson (Achilles). Olsson is back in training after four months on the sidelines, but Albion boss Tony Pulis has conceded the Swede is not yet ready to be included in the squad.
Tottenham head coach Mauricio Pochettino has almost a full squad to select from. The Capital One Cup finalists have a daunting fixture schedule in the coming weeks and Pochettino will be happy to have all but one player at his disposal as Nacer Chadli comes back into contention. Chadli had been away after a family bereavement but Nabil Bentaleb is still at the African Nations Cup after Algeria progressed to the last eight.
Last season: West Brom 3 Tottenham 3, Tottenham 1 West Brom 1
Last five league matches: West Brom L L D W D; Tottenham W D W L W
Top scorers (all competitions): Saido Berahino (West Brom) 14; Harry Kane (Tottenham) 18
Match odds: H 19-10 A 29-20 D 9-4
Referee: Kevin Friend
Chelsea (1) v Manchester City (2), 5.30pm - Live Sky Sports 1
Chelsea striker Diego Costa will miss the Premier League leaders' showdown with Manchester City as he starts his three-match suspension for violent conduct. Cesc Fabregas (hamstring), Filipe Luis (calf) and Branislav Ivanovic (foot) are doubts after suffering injuries in Tuesday's Capital One Cup semi-final defeat of Liverpool, in which Costa was adjudged to have stamped on Emre Can. Gary Cahill is expected to be a substitute once more, with Kurt Zouma continuing in defence, while Andre Schurrle and Mohamed Salah are likely to miss out as reports intensify of imminent moves for the out-of-favour pair.
Manchester City playmaker Samir Nasri could have a chance of featuring at Stamford Bridge. The Frenchman has missed the last two games with a calf injury but has made good progress and will be assessed. Defender Eliaquim Mangala will also have a shoulder problem checked while midfielder Yaya Toure and new signing Wilfried Bony are away at the African Nations Cup.
Last season: Man City 0 Chelsea 1, Chelsea 2 Man City 1
Last five league matches: Chelsea W D L W W; Man City W D W D L
Top scorers (all competitions): Diego Costa (Chelsea) 17; Sergio Aguero (Man City) 19
Match odds: H 1-1 A 11-4 D 5-2
Referee: Mark Clattenburg
Arsenal (5) v Aston Villa (15), 1.30pm - Live Sky Sports 1
Arsenal forward Alexis Sanchez (hamstring) is doubtful, while new signing Gabriel Paulista could make the squad after joining from Villarreal. England striker Danny Welbeck (thigh) is close to a return but may not be risked, while midfielder Alex Oxlade-Chamberlain (groin) is also expected to come into contention ahead of the north London derby at Tottenham next weekend. Midfielders Jack Wilshere (ankle), Mikel Arteta (ankle) and Abou Diaby (calf) are all still out, as is full back Mathieu Debuchy (shoulder).
Scott Sinclair is likely to go straight into Aston Villa's squad after joining on loan from Manchester City. The winger will train with the side on Saturday before boss Paul Lambert makes a final decision on his inclusion. Forward Gabriel Agbonlahor has recovered from a hamstring injury while Joe Cole (also hamstring) is training but not yet fit. Defenders Ron Vlaar (knee) and Philippe Senderos (calf) both remain out.
Last season: Aston Villa 1 Arsenal 2, Arsenal 1 Aston Villa 3
Last five league matches: Arsenal W W L W W; Aston Villa L D D L L
Top scorers (all competitions): Alexis Sanchez (Arsenal) 18; Andreas Weimann (Aston Villa) 4
Match odds: H 1-4 A 12-1 D 9-2
Referee: Anthony Taylor
Southampton (3) v Swansea (9), 4.0pm - Live Sky Sports 1
Sadio Mane and Maya Yoshida will return for Southampton after international duty. Shane Long (ribs), Toby Alderweireld, Victor Wanyama (both hamstring) and Morgan Schneiderlin (adductor) are unavailable due to injury. Sam Gallagher and Jay Rodriguez remain long-term absentees, while Emmanuel Mayuka is also injured.
Saints midfielder Jack Cork is set to become a Swansea player before the game but he will not be involved after completing his move from Southampton. Swansea are without suspended pair Gylfi Sigurdsson and Kyle Bartley following their FA Cup red cards at Blackburn last weekend. But skipper Ashley Williams has recovered from a shoulder problem and Neil Taylor will return after being rested, while Jefferson Montero is in contention to start after marking his comeback from hamstring trouble with a substitute's appearance at Blackburn.
Last season: Swansea 0 Southampton 1, Southampton 2 Swansea 0
Last five league matches: Southampton W D W W W; Swansea W L D D L
Top scorers (all competitions): Graziano Pelle (Southampton) 12; Gylfi Sigurdsson (Swansea) 6
Match odds: H 6-10 A 5-1 D 11-4
Referee: Michael Oliver