Olly Barkley has been ruled out of England's opening autumn Test against New Zealand, on November 5th at Twickenham, after fracturing his right hand.
Barkley suffered the injury - a fracture to his second metacarpal - during Sunday's Guinness Premiership defeat to Saracens.
Barkley had only just returned to action after a stray boot to the testicles forced him to miss two Bath games.
The 24-year-old might well have started against the All Blacks and England head coach Andy Robinson said, "It is unfortunate for Olly and a real blow to Bath and England . . . He is a key member of the squad and we wish him a quick recovery."
Robinson's plans for the autumn series have been blighted by injuries. At the first Loughborough University training camp less than half of England's elite squad were fit.
Barkley joins the likes of Jonny Wilkinson, Steve Borthwick, Steve Thompson, James Simpson-Daniel and Iain Balshaw on the treatment table.
And it leaves Robinson with a major selection worry at inside centre, which has been a problem position since the retirement of Will Greenwood.
One likely scenario is for Robinson to start with Newcastle team-mates Jamie Noon and Mat Tait in the midfield.
The All Blacks are likely to start with Aaron Mauger at 12, a position they regard as a second outhalf role.
Although Noon has played all his Test rugby at outside centre he often operates in the 12 role for Newcastle alongside Tait.
They started together against Wasps on Sunday, scoring a try apiece and switching positions before Noon departed to have stitches applied to a cut head.
Other options for England's inside-centre role include two of the Premiership's most exciting youngsters in Newcastle's Toby Flood and Gloucester's Anthony Allen.
The eventual centre partnership selected for the New Zealand game may well reflect any change in the dynamics of the England management team, following the arrival of Brian Ashton as attack coach and Rob Andrew as director of rugby.