WHO expects around 200,000 Ebola vaccine doses by mid-2015

Trócaire chief says there is a window of six weeks to bring crisis under control

World Health Organisation assistant director general Marie Paule Kieny at a news conference on Ebola vaccines in Geneva yesterday.Photograph: Denis Balibouse/Reuters

World Health Organisation assistant director general Marie Paule Kieny at a news conference on Ebola vaccines in Geneva yesterday.Photograph: Denis Balibouse/Reuters


The World Health Organisation (WHO) set out plans yesterday for speeding up development and deployment of experimental Ebola vaccines, saying hundreds of thousands of doses should be ready for use in west Africa by the middle of 2015.

The Geneva-based United Nations health agency confirmed that two leading vaccine candidates are in human clinical trials, and said another five experimental vaccines were also being developed and would begin clinical trials next year.

“Before the end of the first half of 2015 ... we could have available a few hundred thousand doses. That could be 200,000, it could be less or could be more,” WHO assistant director Marie-Paule Kieny told reporters after a meeting in Geneva of industry executives, global health experts, drug regulators and funders.

Researchers are testing two candidate vaccines from GlaxoSmithKline and NewLink Genetics.

“At least five vaccines are following closely and will be in the clinic in the first months of 2015,” Ms Kieny said. Among those is a potential shot from Johnson & Johnson, which is set to enter human trials in January.

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“Vaccines are not a magic bullet, but when ready they may be a good part of the effort to turn the tide against the epidemic,” Kieny, who has responsibility at the WHO for for health systems and innovation, told reporters.

Experts aim to conduct a range of different clinical trials in Liberia, Sierra Leone and Guinea to produce the first efficacy data by around April, she said. Plans are most advanced for Liberia, where two different Ebola vaccines would be compared against a control, or placebo, vaccine.

Kieny said there was a lot of discussion during the meeting about financing, with a number of entities including the World Bank and the international medical charity Médecins Sans Frontières making commitments to help fund Ebola vaccine trials, distribution and deployment.

Drugmakers had also pledged to ensure any shots they do development would be priced at an affordable level. “There is a broad understanding that money will not be an issue,” Kieny said. “And on commitment of vaccine manufacturers, of course there is commitment for affordable prices.”

Drugmakers have said they are ready to work together to speed up the development and production of Ebola vaccines.

Accelerated trials

Rolling out a mass immunisation programme would not happen until much later, when vaccine production has been ramped up.

GlaxoSmithKline chief executive Andrew Witty said on Thursday companies would need some kind of indemnity from governments or multilateral agencies for the widespread emergency use of vaccines in Africa, since the usual years-long process of safety testing has had to be shortened to a matter of months.

Kieny said the discussions on financing also included suggestions that a fund could be created to indemnify companies in case people had adverse reactions to the new Ebola shots.


Speaking from the Sierra Leone capital, Freetown, he said health services in west Africa would be over-run if the virus was not brought under control by early December. He called on international governments, including the Irish Government, to increase efforts to halt the rapid spread of the virus. – (Reuters)