Divock Origi and Xherdan Shaqiri were given the difficult job of replacing Mohamed Salah and Roberto Firmino as Liverpool sought to pull off an even tougher task at home to Barcelona in their Champions League semi-final second leg.
The pair were two of four changes made from Saturday's win at Newcastle, with James Milner and Joel Matip coming in for Georginio Wijnaldum and Dejan Lovren with Salah (concussion) and Sturridge the others to miss out, as the Reds sought to overturn a 3-0 deficit.
Teenager Rhian Brewster was named in a matchday squad for only the second time in his Liverpool career as he looked to make his debut, with fellow 19-year-old Ben Woodburn also among the substitutes.
Former Liverpool stars Luis Suarez and Philippe Coutinho were named in Barcelona's side.
LIVERPOOL: Alisson, Alexander-Arnold, Matip, van Dijk, Robertson, Henderson, Fabinho, Milner, Shaqiri, Mane, Origi.
Subs: Mignolet, Wijnaldum, Lovren, Gomez, Sturridge, Brewster, Woodburn.
BARCELONA: Ter Stegen, Sergi Roberto, Pique, Lenglet, Jordi Alba, Vidal, Sergio Busquets, Rakitic, Messi, Suarez, Coutinho.
Subs: Cillessen, Nelson Semedo, Arthur, Malcom, Umtiti, Vermaelen, Alena.
Referee: Cuneyt Cakir (Turkey)