All eyes will be on the in-form Gareth Bale, with memories still fresh of what he did to Internazionale in the Champions League group phase two seasons ago.
It was not only the hat-trick at San Siro but his performance in the White Hart Lane return that advertised his talent to a global audience.
Maicon, the then Inter right-back, was reduced to a wreck. The home crowd will hope for another famous night in a competition Andre Villas-Boas has treated with respect.
Having come this far, the manager is determined to overcome his former club and will name a strong team, with Jermain Defoe set to return to the starting line-up in place of the injured Emmanuel Adebayor.
TOTTENHAM HOTSPUR (4-2-3-1, probable): Friedel; Walker, Gallas, Vertonghen, Assou-Ekotto; Parker, Dembele; Lennon, Bale, Sigurdsson; Defoe.
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