Eddie O'Sullivan has given Leo Cullen and Marcus Horan the chance to impress after announcing the team to take on Fiji in Lansdowne road this Saturday.
The pair will win their first full caps in a team that shows nine changes from the fifteen that beat Australia at the weeekend.
Leicester wing Geordan Murphy and the London Irish duo of Kieran Dawson and Justin Bishop (left wing) have been called up.
In a new-look half back pairing David Humphrey's and Guy Easterby will start at out-half and scrum-half respectively.
Included on the bench are Mick O'Driscoll and Gordon D'arcy, while Eric Miller is back in the fray after injury.
Ireland:G Murphy; S Horgan, B O'Driscoll capt, K Maggs, J Bishop; D Humphreys, G Easterby; M Horan, F Sheahan, J Hayes; L Cullen. M O'Kelly; A Quinlan, K Dawson, A Foley.
Replacements:S Byrne, R Corrigan, M O'Driscoll, E Miller, P Stringer, R O'Gara, G D'Arcy.