Ms CherieBlair was recovering last night after suffering a miscarriage on the eve of a family summer break in France.
The wife of the British Prime Minister was taken to hospital on Monday night after falling ill at Downing Street.
Mr Tony Blair was with her as she underwent an operation at London's Chelsea and Westminster Hospital before being discharged yesterday morning.
Mr Blair remained with his wife at their official country residence, Chequers, as she rested last night after their four children travelled to Toulouse.
Ms Blair's mother, Gale, who has accompanied the Blairs on previous family holidays, is thought to be with Euan (18), Nicky (16), Kathryn (14), and Leo (2).
The Prime Minister and his wife wanted to thank hospital staff for "their support and care", Downing Street said.
"Mrs Blair came through the operation well and is now resting," a spokeswoman said.
"The Prime Minister and Mrs Blair will join the rest of their family later for what they hope will be a quiet holiday."
The Blairs are reportedly heading to Le Vernet, in the Haute-Garonne region, where they are expected to rent Le Chateau du Moulin.
Downing Street appealed for the couple's privacy to be respected, saying they still hoped to "enjoy as normal a family holiday as possible".
Ms Blair is understood to have known she was pregnant.
Her last public appearance was at the closing ceremony of the Commonwealth Games on Sunday night.
Dressed in a plastic poncho, she clapped and sang along to the music with 38,000 spectators at the stadium.
The couple had spent the weekend on a break in Cumbria, aimed at boosting British tourism before heading abroad.
The couple had stunned the country when they announced that Ms Blair was pregnant with their fourth child more than a decade after the birth of Kathryn.
She gave birth in May 2000 at the age of 45 and impressed observers with the speed at which she resumed her career as a high-powered lawyer. -(PA)