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British Prime Minister Theresa  May is facing a no confidence vote after 48 Conservative MPs sent letters indicating a loss of belief in her ability to successfully navigate a Brexit deal. Photograph: Julien Warnand/EPA

Stocks advanced globally following positive signs on the outlook for US-China trade talks, and the pound edged higher even as a vote of confidence in (...)

Members of French special police forces attend a police operation the day after a shooting in Strasbourg, France, December 12, 2018. Photograph: Vincent Kessler/Reuters

A large-scale manhunt is under way for a suspected extremist gunman who killed three people near a Christmas market in Strasbourg on Tuesday. Authori(...)

Adolphe Ndagijimana, his wife, Joy, and their two daughters, Jaissah (18 months) and Janice (3). Photograph: Liam Burke/Press 22

The first time Adolphe Ndagijimana met Joy he knew there was something special about her. It was 1998 and Ndagijimana was only 13, but he made an effo(...)

Retail property is now undergoing an overdue development phase in Dublin  city centre. Photograph: Alan Betson

In any form of investing, it is always difficult to fight sentiment. This is no less true when considering the negative popular perception that surrou(...)

British prime minister Theresa May arrives for a meeting with European Council president Donald Tusk at the European Council in Brussels, Belgium. Photograph: Olivier Hoslet/EPA

Theresa May’s government has promised MPs that the vote on her Brexit deal, which was postponed this week, will take place before January 21st next ye(...)

German chancellor Angela Merkel shakes hands with Britain’s prime minister Theresa May in Berlin on December 11th, 2018. Photograph: Odd Andersen

Jean-Claude Juncker started the day in Strasbourg telling MEPs there was “no room whatsoever for renegotiation” of the Brexit withdrawal treaty. “The (...)

German Chancellor Angela Merkel speaks during the Intergovernmental Conference to Adopt the Global Compact for Safe, Orderly and Regular Migration, in Marrakesh, Morocco . Photograph: Abderrahmane Mokhtari/Morocco

Germany’s chancellor Angela Merkel has said a UN accord on migration is “about nothing less than the foundation of our international co-operation”. M(...)

Venn Life Sciences chief executive Tony Richardson. Venn has established full-service clinical research programmes and activities in 27 different countries

Clinical trials group Venn Life Sciences has signed a strategic collaboration with Open Orphan DAC as it seeks to increase its focus on rare diseases (...)

Britain’s prime minister Theresa May returns to Downing Street after postponing the parliamentary vote on her Brexit deal. Photograph: Ben  Stansall/AFP/Getty Images

Theresa May will start a tour of European capitals on Tuesday to ask for improvements to the Brexit agreement after she called off a parliamentary vot(...)

Dublin’s Iseq index slid to its lowest level since immediately after the Brexit referendum on Monday. Photograph: AFP/Getty Images

Dublin’s Iseq index slid to its lowest level since immediately after the Brexit referendum, as fears mounted over the prospect of the United Kingdom c(...)

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