Father's attack prompted book

Diarmuid Jeffreys became interested in aspirin when his father had a heart attack about 12 years ago.

Diarmuid Jeffreys became interested in aspirin when his father had a heart attack about 12 years ago.

"Fortunately, he recovered and is now fit and well, but from that moment on he began taking a daily dose of aspirin. Even then, I was curious why he was taking what I'd hitherto thought to be a headache pill, but I soon realised that it was because it inhibited blood clotting and lessened the chances of another heart attack.

"The more I read about it - the more I realised that this little chemical marvel which costs about a penny to produce and has the capacity to save lives - had the most incredible history." Hence the book.

He regrets that aspirin has become a victim of its own success. Aspirin has long been approved for use against aches and pains. Formal approval for more serious uses depends on clinical trials.

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"However, the Helsinki Declaration states that researchers may not do anything knowingly to imperil the health of their subjects. Therefore, it is almost impossible for a researcher to give a placebo in an aspirin trial for fear of allowing a patient to have a preventable heart attack."

Also, so many people now know about aspirin's benefits that they won't take part in a trial in which they might be given a placebo instead.

No placebos, no trials, no evidence. So the cheapest and probably most effective weapon against heart and other serious disease is not fully deployed. Catch-22.

To overcome this, scientists are now researching the salicylates in their natural form, as they occur in organic fruit and vegetables. Imagine the day when someone gets a Nobel Prize for medicine for proving that "an apple a day keeps the doctor away".