England 53 South Africa 3
England set a world record of 18 consecutive tests unbeaten at one ground when they scored seven tries in a record defeat of 14-man South Africa at Twickenham.
Two tries from centre Will Greenwood, a penalty try and touchdowns from winger Ben Cohen and back row players Neil Back, Richard Hill and Lawrence Dallaglio clinched the win over the Springboks who were hit by the first-half dismissal of lock Johannes Labuschagne.
England's run of victories beat France's 17-match unbeaten record at the Parc des Princes in the 1980s and Australia's present 17-match stretch at Ballymore in Brisbane.
The victory also completed a clean sweep of all the southern hemisphere powers - New Zealand, world champions Australia and the Springboks - in consecutive tests this month.
England last lost at Twickenham in a World Cup pool game in October 1999 when they were beaten 30-16 by New Zealand. The result marked England's biggest win over the South Africans.
England have never scored as many tries against the 1995 world champions.
Scorers
EnglandTries: Cohen, Greenwood (2), penalty try, Back, Hill, Dallaglio. Conversions: Wilkinson (1), Dawson (1), Gomarsall (2), Stimpson (2) . Penalties: Wilkinson (2).
South AfricaPenalty: Pretorious.
England
Jason Robinson (Sale); Ben Cohen (Northampton), Will Greenwood (Harlequins), Mike Tindall (Bath), Phil Christophers (Bristol); Jonny Wilkinson (Newcastle), Matt Dawson (Northampton); Richard Hill (Saracens), Neil Back (Leicester), Lewis Moody (Leicester); Ben Kay (Leicester), Martin Johnson (Leicester, capt); Phil Vickery (Gloucester), Steve Thompson (Northampton), Jason Leonard (Harlequins)
Replacements used: Lawrence Dallaglio (Wasps), Austin Healey (Leicester), Andy Gomarsall (Gloucester), Danny Grewock (Bath), Tim Stimpson (Leicester)
Replacements unused: Mark Regan (Leeds), Robbie Morris (Northampton)
South Africa
Werner Greeff (Western Province); Breyton Paulse (Western Province), Robbie Fleck (Western Province), Butch James (Natal), Friedrich Lombard (Cheetahs); Andre Pretorius (Lions), Bolla Conradie (Western Province); Joe van Niekerk (Lions), Pedrie Wannenburg (Blue Bulls), Corne Krige (Western Province, capt); AJ Venter (Natal), Jannes Labuschagne (Lions); Deon Carstens (Natal), James Dalton (Falcons), Wessel Roux (Blue Bulls)
Replacements used: Norman Jordaan (Blue Bulls), Brent Russell (Pumas), Lukas van Biljon (Natal), Adrian Jacobs (Falcons), CJ van der Linde (Cheetahs)
Replacements unused: Marco Wentzel (Pumas), Pierre Uys (Pumas)
Sent-off: Labuschagne (23)
Referee: Paddy O'Brien (Nzl)
Att: 75,000