SATURDAY
Aston Villa (12) v Fulham (20)
Paul Lambert faces a striker crisis with Christian Benteke expected to be sidelined for up to six months after suffering a serious Achilles tendon injury in training on Friday, while Gabby Agbonlahor is battling to recover from a sickness bug. Nathan Baker has recovered from a foot injury while Karim El Ahmadi is also set to return to contention after a thigh strain.
Fulham midfielder Scott Parker could return from a knee problem but striker Kostas Mitroglou continues to be sidelined by a knee problem. Defender Fernando Amorebieta returns from suspension after being sent off in the 5-0 defeat by Manchester City.
Last season: Aston Villa 1 Fulham 1, Fulham 1 Aston Villa 0
Last five league matches: Aston Villa L W W L L; Fulham L L W L L
Top scorers (all competitions): Christian Benteke (Aston Villa) 11; Steven Sidwell (Fulham) 7.
Match odds: H 10-11 A 13-5 D 12-5
Referee: Michael Oliver (Northumberland).
Cardiff (18) v Crystal Palace (16)
Ole Gunnar Solskjaer will have Craig Noone available after the winger missed the last three games because of a groin injury. The manager could start with the side that drew 3-3 at West Brom last weekend, although Noone and loan signing Wilfried Zaha, who impressed off the bench at The Hawthorns, will push strongly for inclusion.
Tony Pulis is hoping to have Marouane Chamakh available for selection after he returned to training earlier in the week following four games out with a hamstring problem. Fellow striker Dwight Gayle (ankle) is unlikely to return in time but Pulis has no other injury concerns as he looks to build on the 1-0 win over Chelsea last weekend.
Last season: No corresponding fixture
Last five league matches: Cardiff L W L L D; Crystal Palace D L D L W
Top scorers (all competitions): Fraizer Campbell (Cardiff) 9; Marouane Chamakh (Crystal Palace) 6.
Match odds: H 13-10 A 2-1 D 21-10
Referee: Phil Dowd (Staffordshire)
Chelsea (2) v Stoke (10)
Striker Samuel Eto'o remains out for Chelsea with a hamstring injury but Ashley Cole is back from a knee problem, while Nemanja Matic and Mohamed Salah are available again after being ineligible to face Paris St Germain on Wednesday. Ramires serves the final game of his three-match domestic suspension.
Jonathan Walters returns from suspension for the in-form Potters while on-loan Liverpool winger Oussama Assaidi is close to returning from a knee injury but is not yet back in contention. Defender Robert Huth is out for the rest of the season with his knee injury.
Last season: Stoke 0 Chelsea 4, Chelsea 1 Stoke 0
Last five league matches: Chelsea W W L W L; Stoke W D W W W
Top scorers (all competitions): Eden Hazard (Chelsea) 17; Peter Crouch (Stoke) 9
Match odds: H 1-5 A 12-1 D 9-2
Referee: Lee Probert (Wiltshire)
Hull (14) v Swansea (13)
George Boyd is back for Hull after serving a three-game suspension for being found guilty of spitting at Manchester City's Joe Hart. Hull still deny he intended to do so. Goalkeeper Allan McGregor is still in hospital after suffering a bruised kidney and broken ribs against West Ham and Steve Harper will continue in his place.
Garry Monk is set to select from strength after reporting no fresh injury concerns as the Swans look to make it three games unbeaten following a draw against Arsenal and a resounding 3-0 home win against Norwich last time out.
Last season: No corresponding fixture
Last five league matches: Hull L L W L L; Swansea D L L D W
Top scorers (all competitions): Robbie Brady, Curtis Davies, Matty Fryatt, Nikica Jelavic (Hull) 4; Wilfried Bony (Swansea) 20
Match odds: H 6-4 A 17-10 D 21-10
Referee: Howard Webb (S Yorkshire)
Man City (3) v Southampton (8)
Manchester City are again without top scorer Sergio Aguero although the Argentina striker is back in training after four games out with a hamstring injury. Centre back Matija Nastasic, who has been out for two months with a knee problem, also remains on the sidelines.
Victor Wanyama will be assessed before Southampton's trip to the Eithad. The Kenyan midfielder has been absent for nearly a month with a leg injury but could return, while Nathaniel Clyne (groin), Kelvin Davis (hip) and Maya Yoshida (knee) will all miss out.
Last season: Southampton 3 Man City 1, Man City 3 Southampton 2
Last five league matches: Man City W W W W D; Southampton L W W L W
Top scorers (all competitions): Sergio Aguero (Man City) 26; Jay Rodriguez (Southampton) 17
Match odds: H 1-3 A 13-2 D 19-5
Referee: Chris Foy (Merseyside)
Newcastle (9) v Man Utd (7)
Moussa Sissoko (hamstring) is facing up to three weeks on the sidelines as manager Alan Pardew contends with a worsening injury crisis. The Frenchman will join goalkeeper Tim Krul (shoulder), full back Mathieu Debuchy (groin), midfielder Sammy Ameobi (knee) and sriker Loic Remy (calf) on the casualty list.
Centre backs Chris Smalling (hamstring) and Jonny Evans (calf) have returned to training and are available for the departing champions but full back Rafael (thigh) and midfielder Ryan Giggs (hamstring) are doubts. Left back Alex Buttner (hamstring) is available while Juan Mata and Patrice Evra return after sitting out the 1-1 draw with Bayern Munich, but striker Robin van Persie (knee) is not fit.
Last season: Man Utd 4 Newcastle 3, Newcastle 0 Man Utd 3
Last five league matches: Newcastle W L W L L; Man Utd W L W L W
Top scorers (all competitions): Loic Remy (Newcastle) 13; Robin van Persie & Wayne Rooney (Man Utd) 17
Match odds: H 14-5 A 5-6 D 5-2
Referee: Kevin Friend (Leicestershire)
Norwich (15) v West Brom (17)
Norwich defender Joseph Yobo (calf) will be assessed ahead of the clash at Carrow Road while centre half Michael Turner is back in contention following recovery from a hamstring injury. Winger Elliott Bennett continues his rehabilitation from a long-term knee injury while midfielder Leroy Fer (hamstring) is also still not match fit.
Pepe Mel is set to name forward Saido Berahino in his squad despite the dressing-room fracas that marred last weekend's draw with Cardiff. Defender Jonas Olsson, striker Victor Anichebe, midfielder Claudio Yacob and full back Billy Jones are all back in contention meaning captain Chris Brunt (knee) is the only absentee.
Last season: Norwich 4 West Brom 0, West Brom 2 Norwich 1
Last five league matches: Norwich L D L W L; West Brom D L W L D
Top scorers (all competitions): Gary Hooper (Norwich) 7; Saido Berahino (West Brom) 8
Match odds: H 5-4 A 2-1 D 11-5
Referee: Mark Clattenburg (Tyne & Wear)
SUNDAY
Everton (5) v Arsenal (4)
Everton captain Phil Jagielka (hamstring) and midfielder Steven Pienaar (knee) will both miss out on Sunday. Jagielka has been absent for six matches and will not return until manager Roberto Martinez is sure he is 100 per cent while Pienaar has sat out four games. Midfielder Ross Barkley (calf) should be available after coming off against Fulham last weekend.
Arsenal will have midfielder Aaron Ramsey back in the squad for the first time this year following a thigh injury but full back Kieran Gibbs (ankle) is a doubt. Centre half Laurent Koscielny (calf) and midfielder Serge Gnabry (knee) are out alongside Mesut Ozil (hamstring), Jack Wilshere (foot), Theo Walcott and Abou Diaby (both knee).
Last season: Arsenal 0 Everton 0, Everton 1 Arsenal 1
Last five league matches: Everton W W W W W; Arsenal L W L D D
Top scorers (all competitions): Romelu Lukaku (Everton) 13; Olivier Giroud (Arsenal) 19
Match odds: H 7-5 A 7-4 D 11-5
Referee: Martin Atkinson (W Yorkshire)
West Ham (11) v Liverpool (1)
West Ham captain Kevin Nolan will be fit to face Liverpool despite being forced off late on in Monday night's 2-1 win at Sunderland after feeling tightness in his back. Defender George McCartney (hamstring) is less fortunate and will miss out, while Joey O'Brien (shoulder) and Marco Borriello (calf) are again likely to be sidelined.
Brendan Rodgers has to decide whether to keep faith with an unchanged Liverpool side for the trip to Upton Park after Raheem Sterling replaced Joe Allen last week and produced a man-of-the-match display in the 4-0 home win over Tottenham. Jose Enrique (knee) has been ruled out for the remainder of the season.
Last season: Liverpool 0 West Ham 0, West Ham 2 Liverpool 3
Last five league matches: West Ham L L L W W; Liverpool W W W W W
Top scorers (all competitions): Kevin Nolan (West Ham) 7; Luis Suarez (Liverpool) 29
Match odds: H 6-1 A 4-11 D 7-2
Referee: Anthony Taylor (Cheshire)
MONDAY
Tottenham (6) v Sunderland (19)
Emmanuel Adebayor is back in contention for Spurs although Roberto Soldado and Jan Vertonghen are out. The Togolese striker has missed the last three matches with a gashed heel and hamstring problem, while Vlad Chiriches and Paulinho are also back in contention. Kyle Walker, Erik Lamela and Etienne Capoue remain absent.
Gus Poyet has no fresh injury concerns and the Uruguayan's biggest problem will be to find the best XI to attempt to return from White Hart Lane with something to show for their efforts. Striker Steven Fletcher is yet to be ruled out for the season with an ankle injury, but he remains some way from fitness, while keeper Keiren Westwood (shoulder) is still missing.
Last season: Spurs 1 Sunderland 0, Sunderland 1 Spurs 2
Last five league matches: Spurs W L L W L; Sunderland L D L L L
Top scorers (all competitions): Emmanuel Adebayor & Roberto Soldado (Spurs) 11; Adam Johnson (Sunderland) 10
Match odds: H 8-15 A 9-2 D 14-5
Referee: Lee Mason (Lancashire)