British bookmaker said has closed 14 betting shops in the Republic in the first six months of the year.
Announcing its half-year results today, the company said the lack of gaming machines and a more limited product range made it difficult to achieve good levels of profitability in Ireland.
The London-based company still has 35 betting shops in the Republic.
It said overall first-half profit dropped 26 per cent as it was hurt by horse-race cancellations and results that went in customers' favour.
The company said its online operations, which are being moved to Gibraltar to cut costs, would probably meet analysts' estimates.
First-half net income fell to £58.7 million, or 9.9 pence per share, from £79.7 million, or 16.1 pence per share, a year earlier, it said.
"We are cognisant of rising unemployment and constraints on consumer spending generally," chief executive Officer Ralph said, adding that the flat-racing product is not drawing the crowds like it used to.
Retail net revenue dropped 1 per cent to £393.2 million in the first half. Online revenue rose 58 per cent to £100.1 million, William Hill said in the statement.
Horse- race cancellations in January and February and unfavourable results in March hurt profit, the company said.
In May, William Hill lost money on soccer as the four top Premier League teams, Arsenal, Chelsea, Liverpool and Manchester United, won or tied all their games, benefiting customers, the company said.
Telephone net revenue was down 18 per cent to £18.6 million in the half. William Hill will pay a first-half dividend of 2.5 pence per share, compared with 7.75 pence per share in the year- earlier period.