Scientists need more time to decide whether to mass produce a vaccine against swine flu, the World Health Organization said, as the number of cases topped 6,600 around the globe.
Pharmaceutical companies are ready to begin making a swine flu vaccine - but as the virus may mutate, questions abound: How much should be produced? How will it be distributed? Who should get it?
The expert group's recommendations will be passed to WHO Director-General Margaret Chan, who is expected to issue advice to vaccine manufacturers and the World Health Assembly next week.
WHO's flu chief said the meeting of industry representatives and independent experts sought to answer questions including when to recommend to manufacturers that they switch from a seasonal vaccine to one that works against the pandemic strain.
"No big decisions, no announcements," Keiji Fukuda told reporters after the meeting. "These are enormously complicated questions, and they are not something that anyone can make in a single meeting."
But some feel the main decision has already been made.
"It's a foregone conclusion," said David Fedson, a vaccines expert and former professor of medicine at the University of Virginia. "If we don't invest in an H1N1 (swine flu) vaccine, then possibly we could have a reappearance of this virus in a mild, moderate, or catastrophic form and we would have absolutely nothing."
Most flu vaccine companies can only make one vaccine at a time: seasonal flu vaccine or pandemic vaccine. Production takes months and it is impossible to switch halfway through if health officials make a mistake.
Vaccine makers can make limited amounts of both seasonal flu vaccine and pandemic vaccine - though not at the same time - but they cannot make massive quantities of both because that exceeds manufacturing capacity.
"What is really going to be wrestled with is that seasonal influenza itself has a significant impact on people," said Fukuda. "This is an infection which is estimated to kill some hundreds of thousands of people each year around the world, so there is a real trade-off if you just say we're going to stop making that vaccine."
At the moment, health officials aren't sure how deadly swine flu is, and whether they will need more seasonal flu vaccine or swine flu vaccine. And if the swine flu mutates, scientists aren't sure how effective a vaccine made now from the current strain will remain.
WHO estimates that up to 2 billion doses of swine flu vaccine could be produced every year, though the first batches wouldn't be available for four to six months.
The US Centers for Disease Control and Prevention is currently working on a "seed stock" to make the vaccine, which should be ready in the next couple of weeks. That will be distributed to manufacturers worldwide so they can start producing the vaccine.
Until vaccine manufacturers get the seed stock, they won't know how many doses of vaccine they can make or how long that would take. Sanofi Pasteur, the world's biggest vaccine producer, said Thursday it is waiting for the green light from WHO before it starts making swine flu vaccine.
WHO is also negotiating with vaccine producers like GlaxoSmithKline PLC to save some of their swine flu vaccine for poorer nations. Many rich nations like Britain, Canada, Denmark, France, Switzerland and the United States signed deals with vaccine makers years ago to guarantee them pandemic vaccines as soon as they're available.
As yesterday, at least 33 countries reported more than 6,600 cases of swine flu worldwide, with 70 deaths. The figures are based on tallies provided by national governments and WHO. According to the global body's pandemic alert level, the world is at phase 5 - out of a possible 6 - meaning that a global outbreak is "imminent."
North America has been the hardest-hit continent. The United States has reported 3,352 laboratory-confirmed cases of swine flu, including four deaths. Arizona officials reported Thursday the latest case, a woman in her late 40s who died last week from what appeared to be complications from the illness.
New York City closed three schools yesterday in response to a swine flu outbreak that has left an assistant principal in critical condition and sent hundreds of kids home with flu symptoms, in a flare-up of the virus that sent shock waves through the world last month.
Mayor Michael Bloomberg said that four students and the assistant principal have documented cases of swine flu at a Queens middle school.
Mexico has 2,656 cases and 64 deaths, while Canada has 389 cases with one death, according to WHO figures.
Mexico confirmed 374 more cases Thursday including four more deaths, but Health Secretary Jose Angel Cordova said the new cases show the virus is appearing less deadly. Mexico's swine flu deaths now represent 2.4 percent of its confirmed cases, he said.
Spain and Britain have the most cases in Europe, at 100 and 78 respectively.
In Central America, Costa Rica has eight cases and one death and Panama has 29 cases.
AP