Leicester's valiant battle against relegation from the Premiership ended after they drew today and Manchester City beat Newcastle.
And Wolves' top-flight existence is all-but mathematically over despite their 2-1 win over Everton as their goal difference is so abysmal.
Paulo Wanchope's bullet header from Nicolas Anelka's cross in the 59th minute for the only goal of the game also vastly improved their chances of beating the drop.
Leicester surrendered the fifth-minute lead given to them by Marcus Bent as first Jon Fortune knocked in Paolo di Canio's 53rd-minute corner and then Nikos Dabizas was controversially sent off for bringing down Jonatan Johansson in the penalty area. Di Canio coolly slotted home the spot-kick to send the Foxes down.
Although Wolves moved off the bottom of the table their goal difference is woeful - they can only equal the number of points Manchester City now have and are 36 goals worse off.
Wolves fought back from 1-0 as early as the third minute after Leon Osman marked his Everton debut with a goal. But Henri Camara blasted home a 55th-minute equaliser and Carl Cort snatched a winner six minutes from time.
Second-placed Chelsea opened up a three-point lead on Manchester United after the Stamford Bridge side beat Southampton 4-0 while the Red Devils suffered a shock 1-0 defeat at Blackburn.
After a goalless first half at Stamford Bridge Jimmy Floyd Hasselbaink's corner hit Martin Crainie on the head and went past Antti Niemi just before the hour.
Frank Lampard scored twice in eight minutes late on and Glen Johnson rounded off the scoring five minutes from time.
Jon Stead's 85th-minute strike was enough to account for United, who were without Ruud van Nistelrooy, Roy Keane and Louis Saha.
PA