Former US Senator and Treasury Secretary Lloyd Bentsen, who ran unsuccessfully for vice president in 1988, died on Tuesday at the age of 85, a family spokesman said.
Mr Bentsen's tall stature and southern drawl gave him a gentlemanly air, but the Texas Democrat is perhaps best known for his verbal ferocity in denouncing his 1988 Republican opponent, Sen. Dan Quayle, as "no Jack Kennedy."
Mr Bentsen had been in ill health since suffering two strokes in 1998 that left him confined to a wheelchair and unable to speak very well.
He came from a wealthy family in far south Texas and rose through the political ranks to become one of the last in a long line of powerful Democrats from the state, which now is dominated by Republicans.
Mr Bentsen was elected to the US Senate in 1970, ousting liberal incumbent Ralph Yarborough in the Democratic primary, then defeating Republican and future President George H.W. Bush in the general election.
Six years later, he made a run for the Democratic presidential nomination, but pulled out after losing in early caucuses to the eventual winner, Jimmy Carter.
Mr Bentsen, a moderate, pro-business Democrat, chaired the powerful Senate Finance Committee from 1987 through 1992. When Bill Clinton became president the following year, he tapped Mr Bentsen to be his Treasury secretary.
In 1988, Mr Bentsen was the running mate for Democratic presidential nominee Michael Dukakis when the Texan faced Quayle in a nationally televised vice presidential debate.
After the 41-year-old Mr Quayle claimed to have as much experience in Congress as John Kennedy did when he ran for president, Mr Bentsen, then 67, said scornfully: "Senator, I knew Jack Kennedy. I served with Jack Kennedy. Jack Kennedy was a friend of mine. Senator, you're no Jack Kennedy."
The exchange was regarded as devastating to Mr Quayle, but the Dukakis-Bentsen ticket lost the election. In Washington, politicians on both sides of the aisle praised Bentsen as a good public servant.
"Lloyd Bentsen's distinguished career earned him a reputation as a giant in Texas politics. He was a powerful voice for our state, and he will be deeply missed," said US Senator John Cornyn, a Republican from Texas.