Covid-19: South Africa stops use of AstraZeneca jab over failure to protect against variant

South Africa halted use of the AstraZeneca-Oxford coronavirus vaccine on Sunday after evidence emerged that the vaccine did not protect clinical trial volunteers from mild or moderate illness caused by the more contagious virus variant that was first seen there.

The findings were a devastating blow to the country’s efforts to combat the pandemic. Scientists in South Africa said that a similar problem held for people who had been infected by earlier versions of the coronavirus: The immunity they acquired naturally did not appear to protect them from mild or moderate cases when they were reinfected by the variant, known as B.1.351.

The developments, coming nearly a week after one million doses of the AstraZeneca-Oxford vaccine arrived in South Africa, were an enormous setback for the country, where more than 46,000 people are known to have died from the virus. They were also another sign of the dangers posed by new mutations in the coronavirus.

The B.1.351 variant has spread to at least 32 countries. The number of cases evaluated as part of the studies outlined by South African scientists were low, making it difficult to pinpoint just how effective or not the vaccine might be against the variant. And because the clinical trial participants who were evaluated were relatively young and unlikely to become severely ill, it was impossible for the scientists to determine if the variant interfered with the AstraZeneca-Oxford vaccine’s ability to protect against severe Covid-19, hospitalisations or deaths.

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The scientists said, however, that they believed the vaccine might protect against more severe cases, based on the immune responses detected in blood samples from people who were given it. If further studies show that to be the case, South African health officials will consider resuming use of the AstraZeneca-Oxford vaccine, they said.

The new research findings have not been published in a scientific journal. But the discovery that the AstraZeneca-Oxford product showed minimal efficacy in preventing mild and moderate cases of the new variant added to the mounting evidence that B.1.351 makes current vaccines less effective.

‘Reality check’

Pfizer and Moderna have both said that preliminary laboratory studies indicate that their vaccines, while still protective, are less effective against B.1.351. Novavax and Johnson & Johnson have also sequenced test samples from their clinical trial participants in South Africa, where B.1.351 caused the vast majority of cases, and both reported lower efficacy there than in the United States.

“These results are very much a reality check,” Shabir Madhi, a virologist at University of the Witwatersrand who ran the AstraZeneca-Oxford vaccine trial in South Africa, said of the findings released Sunday.

The pause in the country’s rollout of the AstraZeneca-Oxford vaccine means that the first shipments will now be put in warehouses. Instead, South African health officials said they would inoculate health workers in the coming weeks with the Johnson & Johnson vaccine, which has shown strong efficacy in preventing severe cases and hospitalisations caused by the new variant.

Johnson & Johnson has applied for an emergency use authorisation in South Africa. But health officials there indicated that even before it is authorised, some health workers could be given the vaccine as part of an ongoing trial.

In the AstraZeneca-Oxford trial in South Africa, roughly 2,000 participants were given either two doses of the vaccine or placebo shots. There was virtually no difference in the numbers of people in the vaccine and placebo groups who were infected with B.1.351, suggesting that the vaccine did little to protect against the new variant. Nineteen of the 748 people in the group that was given the vaccine were infected with the new variant, compared with 20 out of 714 people in the group that was given a placebo.

That equates to a vaccine efficacy of 10 per cent, though the scientists did not have enough statistical confidence to know for sure whether that figure would hold among more people. Researchers also conducted laboratory experiments on blood samples from people who had been vaccinated and found a significant reduction in the activity levels of vaccine-generated antibodies against the B.1.351 variant compared with other lineages.

‘Minimal protection’

Beyond the troubling news about the AstraZeneca-Oxford vaccine, Prof Madhi reported evidence suggesting that past infection by earlier versions of the coronavirus did not protect people in South Africa from the B.1.351 variant.

Researchers from the University of Oxford acknowledged that the vaccine provided “minimal protection” against mild or moderate cases involving the B.1.351 variant. They are working to produce a new version of the vaccine that can protect against the most dangerous mutations of the B.1.351 variant, and have said they hope it will be ready by the fall.

"This study confirms that the pandemic coronavirus will find ways to continue to spread in vaccinated populations, as expected," Andrew Pollard, the chief investigator on the Oxford vaccine trial, said in a statement. "But, taken with the promising results from other studies in South Africa using a similar viral vector, vaccines may continue to ease the toll on health care systems by preventing severe disease."

Moderna has also begun developing a new form of its vaccine that could be used as a booster shot against the variant in South Africa. B.1.351 has become the dominant form of the virus in South Africa and has been found in several dozen countries. – New York Times