The number of cases of foot-and-mouth has grown to 51 with the confirmation of the disease at three more farms, in County Durham, Tyne and Wear and Herefordshire.
This comes after another case was confirmed in Cumbria.
The outbreaks were found on a pig farm in Hamsterley, Co Durham, a sheep farm in Heddon-on-the-Wall, Tyne and Wear, and a cattle farm in St Weonards in Herefordshire.
It is not immediately known how many animals will have to be slaughtered as a result of the new outbreaks or how the virus had spread to the new locations.
Approximately 45,000 animals have now been slaughtered as a result of the disease, including 6,300 animals which may have come into contact with infected animals.
Earlier the Scottish executive confirmed a fresh case of the disease at a farm in Canonbie, Dumfries and Galloway.
Some local authorities are working throughout the weekend to prepare for a flurry of applications from farmers wanting to move their stock to abattoirs under the restricted licensing scheme.
Agriculture Minister Nick Brown said: "I would have thought that people would have got their plans all sorted out by Monday and the applications would have been received by then or earlier and we would have got products moving by Tuesday or earlier."
He also said that the Government must ensure that the ban was not lifted before appropriate measures were in place to guarantee that the disease had been controlled and eradicated.
Vets from abroad are travelling to England to help inspect the animals.
PA