Qualifier Ivo Karlovic created one of the biggest Wimbledon upsets of all time to defeat defending champion Lleyton Hewitt on Centre Court today.
The 6ft 10ins Croat - ranked 203 in the world - stormed back from a set behind to secure an incredible 1-6 7-6 6-3 6-4 win over the Australian.
Hewitt is the first defending male champion to lose in the first round since Manuel Santana in 1967.
Only three weeks ago Karlovic had been beaten by Briton Alex Bogdanovic in a Challenger tournament in Surbiton.
But once he found his range with his booming serve and sleek volleys he managed to secure a remarkable win.
A dejected Hewitt said afterwards: "I could have been 6-1 4-0 up and I just didn't take my chances.
"If I got on top of him it makes life a lot tougher for him to come out and keep serving.
"I gave him his chances and to his credit he picked up and his game got a lot better.
"At the end of the day I'd be disappointed losing in the first round at Wimbledon at any time.
"You've got to deal with it - it's hard at the moment trying to say you can learn from it but hopefully I can, see where things went wrong.
Queen's Club winner Andy Roddick looked in fine form as he swept aside Davide Sanguinetti in his opening match.
The fifth-seeded American beat his Italian opponent in straight sets on Court One to set up a possible clash with Briton Greg Rusedski.
Roddick's famous serve was working well and he had few problems in winning 6-2 6-3 6-3.
Roddick is clearly in confident mood. Afterwards he said: "If I had to pick six guys to win the tournament I might throw myself in there. After Queen's there is more attention on me now but it's not a total shock - it comes with the territory."
Roddick also expressed his shock at Hewitt's early loss.
He added: "If you play a tall guy like that who is serving out of the trees it is always going to be tough.
In the women's singles, there were routine wins for the leading seeds in the bottom half of the draw - Kim Clijsters and Venus Williams.
Clijsters was in no mood to follow in the footsteps of boyfriend Hewitt as she romped to a 6-0 6-0 victory against Paraguay's Rossana Neffa-De Los Rios.
At just 32 minutes, it was one of the tournament's quickest ever matches. Meanwhile, Williams beat little-known Slovakian qualifier Stanislava Hrozenska 6-2 6-2.
Lindsay Davenport was given more of a workout but still managed to beat Australian Samantha Stosur. The 1999 champion withdrew during the French Open earlier this month with a toe injury and had been doubtful for Wimbledon.
But she showed she has the fighting spirit required, battling hard for a 7-6 7-5 win.
Two women's seeds did make an early exit though.
Israeli Anna Pistolesi was beaten 6-4 6-4 by American Samantha Reeves, and Patty Schnyder (20) lost 7-6 6-3 to Hungary's Petra Mandula.