Over 1.6 million counterfeit cigarettes and 325 bottles of vodka have been seized by officers from Revenue's Customers Service.
The seizure took place yesterday in Co Louth where one person was arrested.
The seized goods had an estimated retail value of €720,000 with a potential loss to the exchequer of €603,000.
The latest seizure follows on from the discovery of 300,000 illegally imported cigarettes which were detained along with two cars in Co Cavan on Tuesday.
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Two people were questioned in relation to the seizure which had an estimated retail value of €200,000 with a potential loss to the exchequer of €114,000.
A file is currently being prepared for prosecution.