The New York Stock Exchange: US and European equities extended their weekly gains on Wednesday. Photograph: Michael Nagle/Bloomberg

European shares rose for a third straight day on Wednesday as optimism around a potential Covid-19 vaccine and comments from European Central Bank (EC(...)

Cardiovascular diseases account for 36%  of deaths in Ireland. High blood pressure is experienced by one in four Irish men. All told around 10,000 people in Ireland die from heart disease every year

The pandemic has prompted many people in Ireland to postpone out-patient cardiovascular appointments, but studies are emerging that show SARS-CoV-2 ma(...)

BioNTech plans to produce 50 million doses of the new vaccine before the end of the year and up to 1.3 billion in 2021. Photograph: Ronald Wittek/EPA

German immunotherapy company BioNTech is based in Mainz with the postal address “An der Goldgrube”, which translates variously as “On the Goldmine”, “(...)

Gabriel García Márquez in Mexico City in 1976. Photograph: Alan Riding/The New York Times

King Kong Theory By Virginie Despentes, translated by Frank Wynne Fitzcarraldo Editions, £10.99 When I grow up, I want to be Virginie Despentes. The (...)

Technology stocks pushed Wall Street indices sharply higher on in early trading on Wednesday as the initial vote count pointed to a close race for the White House. Photograph: Kena Betancur/AFP

European shares closed higher after a choppy start to the day’s trading, influenced by the closeness of the US presidential race between Democratic ca(...)

The New York Stock Exchange on Wall Street, where trading has turned volatile due to surging Covid-19 cases. Photograph: Angela Weiss/AFP

European stocks suffered their sharpest drop in five weeks as Germany announced a new lockdown to combat a surge in Covid-19 cases, while restrictions(...)

Gabriel Makhlouf: “There is a whammy from the pandemic that is hitting particular sectors hard and then we have the added whammy of Brexit.” Photograph: Nick Bradshaw

The Republic will be the euro zone’s biggest loser from a no-deal Brexit, which threatens to cause an economic “double whammy” on top of the fallout f(...)

The Land Rover Defender: “Finished on the stunt course, I plod back to base. I think I’ve covered myself more in mud than glory, and Commander Bond remains elusively un-caught.”

It stands tall against a background of green grass, intimidatingly black all over. Arguably more intimidating again thanks to Russian number plates. (...)

France registered more than 30,000 virus cases on Thursday, its highest single-day jump since the pandemic began. Photograph: Getty Images

French restaurants, cinemas and theatres are trying to figure out how to survive a new curfew aimed at stemming the flow of record new virus infection(...)

The Dublin index was also supported by a 1.7 per cent gain for packaging giant Smurfit Kappa, which closed at €35.20.

European markets were mostly flat on Wednesday following losses the day before, with trading muted and the mood among investors cautious rather than p(...)

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