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Ivan Coulter from Sigmoid Pharma, winner of the inaugural ‘Innovation of the Year’ Award and also named winner of the Application of R&D Category.

“Innovation . . . is the application of imagination. There are plenty of success stories . . . but that’s the easy pill to swallow. The bitter one is (...)

Video poker machines in the casino of the Mandalay Bay in Las Vegas,. Gambling on high stakes video poker machines was a defining aspect in the life of Stephen Paddock. Photograph: Eric Thayer/The New York Times

The video poker machines that Stephen Paddock liked were the ones that did not draw attention. They had few look-at-me flashing lights or listen-to-me(...)

Mandalay Bay massacre: people run for cover at the Route 91 Harvest festival in Las Vegas. Photograph: David Becker/Getty

10pm in Las Vegas It is a warm night in the gambling capital of the United States, and more than 22,000 country-music fans of all ages, including chi(...)

 US team member Phil Mickelson sits with wife Amy, son Evan and daughter Sophie by the eighth green  at the 2017 Presidents Cup. Photograph:  Andrew Gombert/EPA

Spectators ringed the 17th green at Liberty National on Saturday, many of them yelling terms of endearment at Phil Mickelson. “Hoboken loves you, Phi(...)

Wood-burning oven at Hartwood, Tulum. From ‘Hartwood’ by Eric Werner and Mya Henry (Artisan Books). Photograph: by Gentl & Hyers

Salt is the only thing I can taste at first in Noma Mexico. Over-seasoning. I lick my chops. A salty amuse bouche. Although it’s not over-seasoned by (...)

An Irish student is receiving treatment in a San Diego hospital after he was allegedly attacked following a night out. File photograph: Getty Images/Flickr RF

Detectives will attempt to speak to an Irish J1 student who was left unconscious following an alleged attack in San Diego. Evan White, a student fro(...)

Helmut Igel surfs under a full moon near San Diego in California. Photograph:Donald Miralle/The New York Times

The ocean and the sky melted together in a grey mass, making it tough for the surfer to size up the coming waves. Would they crash down on top of him (...)

An existing  section of the border fence separating Mexico and the United States, on the outskirts of Tijuana, Mexico: the new wall is required to feature an “aesthetically pleasing” colour – on the US side.  Photograph: Edgard Garrido/Reuters

Wednesday marks the deadline for the hundreds of companies interested in building US president Donald Trump’s signature campaign promise – a “great, g(...)

The tranche of 3.16 million shares in Bulmers maker C&C bought by Brandes Investment Partners was valued at at more than €12 million. Photograph: Bryan O’Brien

US billionaire activist shareholder Charles Brandes must be developing a taste for Irish cider as his firm boosted its stake in Bulmers maker C&C(...)

Bagpipers march during the St Patrick’s Day parade in New York. File photograph: Jewel Samad/AFP/Getty Images

Eurozone countries and markets in North America and the Far East will be the focus for this year’s St Patrick’s Day programme of Ministerial travel, w(...)

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