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Purdue Pharma, the pharmaceutical company that makes OxyContin, is owned by the billionaire Sackler family. Photograph: Justin Lane/EPA

Purdue Pharma has pleaded guilty to criminal charges over the handling of its addictive prescription painkiller OxyContin, capping a deal with federal(...)

A stroller is carried down the stairs at the 53rd Street & Seventh Avenue station in New York on Tuesday. Photograph: Gabriela Bhaskar/The New York Times

A young mother has died after falling down stairs at a Manhattan subway station while holding her one-year-old daughter. Malaysia Goodson, from Stamf(...)

Jean Pierre Bars and his wife Maria Harte Bars during consultation at the Dublin Neurological Institute.  Marie has a gene mutation which caused a genetic disorder with symptoms of both Parkinsons and Dementia. Photograph Nick Bradshaw

It has been 23 years since Frenchman Jean-Pierre Bars attended a job interview in Greenwich, Connecticut, for a restaurant manager position. Sitting a(...)

Howard Millar: last  year joined Stellwagen as chief operating officer and as as chief executive of one of its divisions, Stellwagen Capital.  Photograph: Bryan O’Brien

Howard Millar and two other executives are leaving Irish- and US-based aviation leasing specialist Stellwagen Group in a surprise move. Mr Millar, Ry(...)

Gene Wilder secured his place in Irish cinema history as the star of Waris Hussein’s 1970 comedy ’Quackser Fortune Has a Cousin in the Bronx’. Photograph: Mychele Daniau/AFP/Getty Images

Gene Wilder, one of cinema’s great neurotics, has died of complications from Alzheimer’s disease at the age of 83. Wilder had worked only erratically (...)