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An image from a video posted on social media of a  tornado  in Mangum, Oklahoma. Photograph:  Lorraine Matti via Reuters

A “violent tornado” has touched down in Missouri, causing possible fatalities and heavy damage, according to the US National Weather Service. The ser(...)

Among those who worked on the railway were thousands of post-Famine Irish emigrants. File photograph: Getty

On this day 150 years ago one of the most important events in American history took place. A golden spike was driven into the ground to mark the com(...)

Tana French: the Irish crime author’s new novel is The Wych Elm. Photograph: Tom Honan

When the Irish crime writer got a rave from the US master, it took her literary journey full circle A few years ago, the crime writer Tana Frenc(...)

In the news: some of the headline-makers of 2018

Answer all 100 questions in our special Christmas Quiz to be in with a chance of winning one of the following prizes: 1st prize: One night (...)

Iva Williamson peers behind her as she joins neighbors and pets in fleeing rising flood waters in the aftermath of Hurricane Florence in Leland, North Carolina, September 16, 2018. Photograph: Reuters

The remnants of deadly Hurricane Florence brought more misery to the waterlogged Carolinas on Monday with US officials warning the worst is yet to co(...)

Donald Trump had invited Canada to rejoin the trade talks but warned that the US was prepared to plough ahead with a bilateral deal with Mexico, ending the three-country structure of Nafta, if Ottawa did not sign on quickly.

Donald Trump’s deal with Mexico to revamp Nafta has opened a new rift with Congress over trade after senior lawmakers reacted sceptically to parts of (...)

Brett Kavanaugh has refused to answer whether Donald Trump can be forced to comply with a subpoena. Photograph: Mandel Ngan/AFP/Getty Images

Republican elected officials have hesitated to criticise Donald Trump after his former lawyer Michael Cohen pleaded guilty to fraud, implicating the p(...)

A Catholic church in Pittsburgh, Pennsylvania. The church   covered up child sexual abuse by hundreds of priests in the state over a period of 70 years, a report has found. Photograph: Jeff Swensen/New York Times

Bishops and other leaders of the Catholic Church in Pennsylvania covered up child sexual abuse by hundreds of priests over a period of 70 years, persu(...)

“The trade war is cutting the legs out from under farmers, and the White House’s ‘plan’ is to spend $12bn   on gold crutches.” Photograph: Getty Images

All eyes were on Jean-Claude Juncker’s meeting with Donald Trump in Washington on Wednesday. But the tensions between the European Union and the Unite(...)

Prof Ken Murphy: ‘I’m a sceptic by nature, so I think almost everything is overhyped. But over time, I’ve learned to keep my mouth shut and stay focused on the science.’

Your work looks at how our immune systems can be ready for different types of attack. Can you tell us a bit more about this? The immune system has a (...)

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