Indianapolis

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The falure of its Alzheimer medicine - known as Solanezumab, or Sola -  wiped $10 billion off Lilly’s market capitalisation in a single day.

The suspense inside the offices of Eli Lilly this autumn was all but unbearable. After working on a drug to fight Alzheimer’s disease for 15 years, em(...)

Ireland’s Nicci Daly in action against the United States.  “Motor racing and hockey . .  They’re not jobs, they’re my hobbies, my passions.” Photograph: David Aliaga/Inpho

Nicci Daly is hardly a stranger to making difficult choices in her sporting life. Back in 2009 that she was playing for the Dublin women’s senior foot(...)

Indiana governor Mike Pence has been selected by Donald Trump to be his running mate. Mr Pence hails from an Irish Catholic family with grandparents from Sligo and Clare. Photograph: Aaron P Bernstein/Getty Images

Presumptive Republican presidential nominee Donald Trump has formally named Indiana governor Mike Pence as his running mate, ending weeks of speculati(...)

Indiana governor Mike Pence, raised in an Irish American Catholic family, might shore up concerns about Mr Trump, the thrice-married former Democrat, among social conservatives. Photograph: John Sommers/Reuters

Indiana’s “Crossroads of America” motto took on new meaning as the midwestern state hosted crunch meetings between Donald Trump and potential running (...)

Dallas Police Chief David Brown  said he was convinced  any hesitation in giving the go-ahead to kill the shooting suspect on Thursday night would have allowed the gunman the chance to harm more police officers. Photograph: Erik S Lesser/EPA

The chief of the Dallas Police Department on Sunday vigorously defended the use of a bomb mounted on a robot to kill a gunman who shot to death five p(...)

Zai Deshields (4) plays at home before her first therapy session, in Stone Mountain, Georgia. Her mother says she has become withdrawn and regressed to baby-talk since recently pulling a handgun out of a backpack while visiting her grandmother in Texas and wounding her uncle in the leg. Photograph: Melissa Golden/The New York Times

Sha’Quille Kornegay, two years old, was buried in a pink coffin, her favourite doll by her side and a tiara strategically placed to hide the self-inf(...)

Donald Trump pays tribute to rival Ted Cruz at his victory party in Trump Tower in Manhattan, describing him as “one hell of a competitor”. Photograph: Lucas Jackson/Reuters

Indiana is described as the “crossroads of America”, and Texas senator Ted Cruz came here hoping that he could find a route out of the midwestern stat(...)

Ted Cruz has suspended his campaign to be the Republican presidential nominee in light of a resounding win for Donald Trump (right) in Indiana.

Businessman Donald Trump scored a resounding victory in Indiana’s Republican primary forcing his chief rival, Texas senator Ted Cruz, to quit the race(...)

Hillary Clinton has 88 per cent of the delegates needed to win the Democratic belt and she leads in the polls in California. Photograph: Eric Thayer/The New York Times

Even their victory-party music after decisive state wins in the north-east on Tuesday night pointed to how Donald Trump and Hillary Clinton are only j(...)

If Donald Trump didn’t kill the ‘stop Trump’ movement with his five primary wins on Tuesday night, he left it badly battered and bruised. Photograph: Julie Jacobson/AP.

If Donald Trump didn’t kill the “stop Trump” movement on Tuesday night, he left it battered and bruised. The Republican front-runner’s case for the (...)

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