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 Traders working the floor of the New York Stock Exchange. The S&P 500  notched a fresh record high on Wednesday as gains in Apple’s shares powered a rally in tech stocks. Photograph: Reuters

Global equities advanced on Wednesday for a fourth straight day of gains as Apple’s strong results soothed concerns about earnings growth ahead of a F(...)

Tesaro brings to GSK a marketed product for ovarian cancer, Zejula, which belongs to a promising new class of medicines.  Photograph: Toby Melville/Reuters

GlaxoSmithKline has agreed to buy US cancer specialist Tesaro for $5.1 billion (€4.5 billion), marking a major biotech investment by chief executive E(...)

Irish Continental Group, the owner of Irish Ferries, suffered a second day of falls

Trading in European shares was hesitant on Wednesday as investors awaited guidance from the US Federal Reserve on future interest rate rises. Trading (...)

 White House chief economic adviser Gary Cohn resigned on Tuesday. Photograph: Reuters

Global investors were largely fretting about the potential of a trade war on Wednesday after the resignation of Donald Trump’s economic advisor Gary C(...)

 National Economic Council director Gary Cohn . Photograph:  Brendan Smialowski/Getty Images

European shares opened lower on Wednesday after the resignation of Donald Trump’s economic adviser Gary Cohn, seen as a bulwark against protectionist (...)

US companies added 263,000 workers in March, the most since December 2014, according to payrolls processor ADP. Photograph: Getty Images/iStockphoto

US companies added 263,000 workers in March, the most since December 2014, suggesting further tightening of the labour market, payrolls processor ADP (...)

The franchise agreement between Air France and Cityjet will end in October when AF  takes back the Dublin-Paris route

Air France from Dublin The franchise agreement between Air France and Cityjet will end in October when the French carrier takes back the Dublin-Paris(...)

Federal Reserve chairwoman  Janet Yellen holds a news conference following the two-day Federal Open Market Committee meeting in Washington. Photograph: Reuters

European shares hit a one-week high on Wednesday before the outcome of a Fed meeting, with banks rallying after a policy overhaul at the Bank of Japa(...)

Exxon Mobil Corp. signage is displayed on a monitor on the floor of the New York Stock Exchange. The S&P 500 fell 0.2 per cent, after losing as much as 0.5 per cent. The Dow Jones Industrial Average declined 0.1 per cent, to 17,771.62. The Nasdaq Composite slipped 0.2 per cent. (

European stocks were little changed after European Central Bank president Mario Draghi kept broadly similar inflation forecasts for the euro area, whi(...)

French president François Hollande  welcomes Iran’s president Hassan Rouhani as he arrives at the Élysée Palace in Paris.  Photograph: Charles Platiau/Reuters

France and Iran “opened a new chapter in our relations” during President Hassan Rouhani’s two-day visit to the French capital, President François Holl(...)

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