Juventus, who suffered their first domestic defeat of the season at the weekend with their 3-1 loss to AC Milan, face the only other team to have beaten them this season when they host Bayern Munich tonight.
Bayern lead Group A after their 2-1 victory over Fabio Capello's side in the last round of games and while Juve - with six points from victories over Club Bruges and Rapid Vienna - are still on course for the knockout stage, they will be keen to avoid another setback.
They will also be keen to keep another clean sheet at home in the competition. If they do they will stretch their record to seven home games without conceding a goal.
Fabio Capello is likely to have Christian Abbiati back in goal after he missed the clash at the San Siro with a knee injury. Abbiati, who is standing in for long-term injury victim Gianluigi Buffon, was replaced by Antonio Chimenti against Milan and the third-choice keeper had a shaky night.
The Juventus coach is unlikely to make any drastic changes to his line-up but Saturday's defeat will leave him pondering some of his selection options.
In attack Alessandro Del Piero, who began on the bench against Milan, will hope to start against the Germans, but that would mean Capello having to leave out either Trezeguet or Swedish striker Zlatan Ibrahimovic.
Another player in contention is Romanian Adrian Mutu who has impressed of late but whose chances of featuring on the right-flank are limited by the presence of Italy international Mauro Camoranesi.
Bayern suffered a big injury setback at the weekend with news that Paraguay striker Roque Santa Cruz will be out for six months with cruciate knee ligament damage. Santa Cruz scored in each of his three previous league games..
Meanwhile, Barcelona striker Lionel Messi is set to be given a starting place as the Catalan club look to ensure their passage into the next round of the Champions League with victory over Panathinaikos at the Nou Camp.
Frank Rijkaard's in-form side lead Group C with seven points and will look to achieve the task they failed to do a fortnight ago when they could only manage a goalless draw in Greece with Samuel Eto'o in particular squandering a number of chances.
Barcelona warmed up for tonight's match with a 5-0 demolition of Real Sociedad at the weekend as they produced some of their best football of the season.
It was their third victory in a row and they are slowly beginning to appear more like the side that won the Primera Liga last spring.
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