A total of 100 new jobs have been announced this morning.
The new positions, which will be created over the next three years, are in the software and medical devices fields.
Irish medical devices firm ClearStream Technologies is to create 70 jobs in Wexford under a major expansion plan, while French financial software firm, Murex have announced the creation of 30 new software jobs. Both companies already have a presence in Ireland.
ClearStream Technologies, which employs 230 workers, designs and manufactures medical devices such as catheters and stents. The new jobs will be in the areas of product engineering, research and development, manufacturing, and sales and marketing.
ClearStream Technologies chief executive, Andy Jones, said that the company was embarking on phase two of the expansion to production capacity to meet the growing demand for the latest generation of its products.
"We intend to seek out new technologies and invest in further research and development for the future and we expect the newly created position of chief technology officer to be key to this growth" he said.
Separately, 30 new jobs have been announced by French software company, Murex.
The jobs, which are supported by the IDA, will be in software development, business development and consulting.
Murex already employs 60 workers in Shelbourne Road in south Dublin.
The new positions are aimed at candidates who have degree or masters qualifications in maths, engineering and computer science.
Managing director of Murex, Francois Pourprix, said that the success of Murex's Irish operation to date has led to the further expansion. "Ireland provides for Murex a pool of highly skilled people from which to choose our workforce, an excellent environment for research and development, and a reputation for success in software development."
Minister O'Keeffe described the investment as an important boost for Ireland's information and communications technology (ICT) sector.
"Eight of the world's top 10 technology firms are based in Ireland so Murex's decision to hire more highly skilled workers in Dublin fits well with the Government's focus on innovative high-tech industry.
"It is significant that Murex, which operates in a technically challenging niche area of the software market, has chosen Ireland for expansion, adding to our strong cluster of global ICT players and acknowledging the strong track record of the Dublin workforce," said Minister O'Keeffe.
