Donald Trump  as he announces his candidacy for the US presidency:  his comments about Mexicans   have made him stand out in a crowded field of Republican candidates. Photograph:  Christopher Gregory/Getty Images

It’s hard to say what’s more shocking: the outrageous remarks property magnate Donald Trump has made since he announced his presidential candidacy or (...)

A makeshift memorial on Boylston Street, near the finish line of the Boston Marathon. A message to Krystle Campbell, one of three people killed in two bomb blasts at the race two years ago, and a Champagne bottle adorned the site a day after Dzhokhar Tsarnaev was sentenced to die for his role in the attack. Photograph: Seán Proctor/The New York Times

A Kazakh exchange student who was friends with the Boston Marathon bomber was sentenced to 3½ years in US federal prison on Friday for removing a back(...)

The Edward M Kennedy Institute opens on March 30th on the campus of the University of Massachusetts Boston, dedicated to the late US senator Edward Kennedy, pictured here (front) with Al Gore in 2000. Photograph: Jim Bourg/Reuters

Minister for Foreign Affairs Charlie Flanagan paid tribute to late US senator Edward Kennedy at a event in Boston last night ahead of today’s official(...)

EU commissioner Máire Geoghegan-Quinn and Theresa Crotty at yesterday’s launch in Dublin. Photograph: Paul Sherwood

A major new research programme aimed at creating new technologies to enhance the lives of people with autism and intellectual disabilities has been la(...)

US researchers say they have demonstrated a way to “silence” the extra chromosome responsible for Down syndrome.

Down Syndrome Ireland has given a cautious welcome to news that scientists in the US have been able to switch off or “silence” the extra chromosome re(...)

Pope Francis blesses a child with Down syndrome at St Peter’s Square in the Vatican. Photograph: AFP/Getty

A way to “switch off” the genetic defect responsible for Down syndrome has been developed by scientists.The technique has only been tried on laborator(...)

Garrett Plath (left), 20, and Kyle Senechal (centre), 21, both of North Attleborough, protest outside the Dyer-Lake Funeral Home. Photograph: Jessica Rinaldi/Reuters

The body of Boston Marathon bombing suspect Tamerlan Tsarnaev, who was the subject of a massive manhunt and died after a gun battle with police(...)