Secretary of state John Kerry: Voting against Iran nuclear deal would be a “self-destructive blow to our nation’s leadership”. Photograph: Getty Images

President Barack Obama has scored a major victory by securing the support of Democrat Barbara Mikulski as the 34th senator to back his nuclear deal wi(...)

 Syrians gather at the site of a car bombing after a rare attack on the port city of Latakia. Photograph: AP

At least 10 people were killed and dozens wounded when a car bomb exploded in the Syrian city of Latakia yesterday, state television said, in a rare a(...)

The Temple of Bel before and after the destruction at  Palmyra. Photograph: AFP/Getty Images

Satellite images have revealed the destruction by Islamic State of the iconic 2,000-year-old Bel temple in the ancient Syrian city of Palmyra just fiv(...)

Former Florida governor and Republican candidate for president Jeb Bush speaks to  third graders before  taking part in a town hall meeting at La Progresiva Presbyterian School in Miami, Florida, September 1st, 2015. Photograph: Joe Skipper/Reuters

Republican presidential hopeful Jeb Bush offered his most direct assault on rival Donald Trump to date on Tuesday, retaliating for a series of persona(...)

The site of a Saudi-led air strike in Yemen’s capital Sanaa on Sunday. Photograph: Reuters/Khaled Abdullah

An air strike by warplanes from a Saudi-led coalition, which said it targeted a bomb-making factory, killed 36 civilians working at a bottling plant i(...)

A 19-year-old Yazidi woman, one of hundreds who says she was taken into sexual slavery by the Islamic State group, now living at a refugee camp in Qadiya, Iraq. Photograph: Mauricio Lima/The New York Times

Islamic State atrocities have descended like distant nightmares upon the numbed conscious of the world. The first beheadings of Americans had the powe(...)

The sons of Khaled al-Asaad, the late 83-year old retired chief archaeologist of the ancient Syrian city of Palmyra, Omar and Mohamad, display a portrait of their father during a ceremony in his memory at the National Museum in Damascus. Photograph: Louai Beshara/AFP/Getty Images

The beheading by Islamic State of Palmyra’s guardian angel archaeologist Khaled al-Asaad (83 ) and the demolition of the iconic Baalshamin temple in t(...)

Syrian migrants on an overcrowded dinghy try to disembark on the shore of the Greek island of Kos this week. Photograph: EPA/YANNIS KOLESIDIS

The beheading earlier this week of Khaled al-Asaad, an 83-year-old archaeologist, by Islamic State militants in the Syrian city of Palmyra brings into(...)

‘If Obama vetoes a resolution of disapproval, it will take 34 senators to override his veto and block the agreement. That means opponents have to find an unlikely 11 more Democrats. Photograph:  REUTERS

It would not be unusual for members of the US Congress to vote against an international agreement, denouncing it with rhetorical flourishes as appalli(...)

The unmanned aerial vehicle is, we are told, the new wonder weapon in the “War on Terror”. Circling over Somalia, Pakistan, Yemen or Gaza, these pi(...)