Pfizer had expected cholesterol drug bococizumab to deliver sales of almost $1 billion a year. Photograph: Dan Kitwood/PA Wire

Project promising 1,250 construction roles pulled after failure of key cholesterol drug

Visitors  at the 186th RHA annual exhibition, includes painting, sculpture, photography, print, drawing and architectural models. Photograph: Cyril Byrne

Sales down 23% on 2015, but record attendence figures suggests revival of interest in art

Tysabri, the multiple sclerosis drug developed by Elan, may be sold again as Perrigo examines options.

CEO John Hendrickson says drug faces increased competition and potential for wider use has failed to materialise

Buying a house: the rules of the Help-toBuy scheme keep changing as the proposal works its way through the Oireachtas to become law. Photograph: Dominic Lipinski/PA Wire

I’m getting a loan of 72% of the house price. Do I qualify for a grant under the scheme?

Taking on the role of landlord when renting out your apartment can be a 24/7 responsibility and  does not suit everyone. Photograph: Brenda Fitzsimons / THE IRISH TIMES

People invariably underestimate the costs involved in maintaining a rental property

Pensioners protest outside Government Buildings last year. By 2055,  just two people are estimated will be working for every person in retirement, compared to about five today. Photograph: Dara Mac Dónaill/The Irish Times

Report urges introduction of mandatory savings to reduce pressure on State pension

Caroline Spillane, director general of Engineers Ireland

Survey of members of Engineers Ireland working in Ireland or Britain reveals that 40 per cent have had commercial deals deferred o(...)

Revenue will not be handling any applications for rebates under the first-time buyer help-to-buy scheme until January 1st. Photograph: Joe St Leger

Rules for first-time buyer rebate differ depending on a range of circumstances

 Industry sources say the State  lost between €4 million and €5 million by the delay in reducing the price of Pfizer’s  blockbuster arthritis drug  Enbrel. Photograph: Paul Faith/AFP/Getty Images

Even with 30% cut in Pfizer’s blockbuster Enbrel, Biogen’s Benepali delivers extra savings for health budget

Nuritas chief executive Emmet Browne said diabetes prevention was the first important area of focus for the company, though it expects to target other conditions in future

Company founded by Trinity mathematician secures €3m from EU to fund trials in Ireland

Dublin TDs and property interests are to the fore of lobbying for amendments to the Finance Bill in relation to the help-to-buy scheme, citing unfair advantage for rural dwellers.

Intensive lobbying is taking place in relation to possible amendment to Finance Bill

Pfizer’s  Enbrel lost patent protection in Europe earlier this year. Biogen introduced Benepali into the Irish market in September

Price drop is first under pricing deal signed by Government and Irish Pharmaceutical Healthcare Association

Buying a house: just because the minimum requirement is 70 per cent does not mean you must borrow only 70 per cent. Photograph: Paul Faith/PA Wire

Q&A: Dominic Coyle answers your personal finance questions

A Revenue spokeswoman said the delay was in advance of “a greater clampdown on offshore assets next year”. File photograph: iStock

People with offshore income and assets warned to settle outstanding liabilities

Minister for Finance Michael Noonan has moved to close off a loophole that allowed holders of certain pensions avoid tax. Photograph: Alan Betson

Holders could avail of tax relief but pay no tax on funds that were then passed on to next generation

 Minister for Finance Michael Noonan: Tax evaders have been given six months to get their affairs in order in relation to offshore assets under the Finance Bill. The measure is likely to lead to a cash windfall for the Revenue between now and the end of April next year. Photograph: Barbara Lindberg

Revenue in line for windfall as Finance Bill sets May 1st deadline for putting affairs in order

Even with a maximum rebate, a couple buying a €400,000 home will need to find €38,000 for their deposit. Photograph: Peter Byrne/PA Wire

Threshold for first-time-buyer scheme reduced to 70 per cent of property’s value

Where a generic medicine is a cheaper identical “copy” of a branded traditional small molecule drug, biosimilar are “me-too” versions of modern, large molecule complex biologic medicines

Drug manufacturers’ lobby group Ipha urges caution over study of competing treatments

There had been fears that close to 200 jobs at the EMC Cork plant could be at risk but staff say the number is now likely to be closer to a quarter of that figure.

Job losses expected to number about 50 as business is merged with Dell after takeover

Mel Gibson  on the set of his latest movie, The Professor and the Madman, which he is shooting in Dublin city and Ardmore with Sean Penn

Bray studios put on the market following three highly successful years financially

How much of a rebate you can claim in any one year will likely be set down in the Finance Bill

Precise detail of Help-to-Buy rebate scheme will not be clear until the Finance Bill is passed

Liberties Press faced bills of €267,802 over the 12 months to the end of July 2016. Photograph: iStockPhoto

It has made efforts to cut costs but has seen an increase in money debtors owes to it

The Joe Duffy group has 14 dealerships across the State representing 15 brands

Motor retailer says its financial performance was ‘extremely encouraging’

Jayne Brady, partner at Kernel with  Bob Pollard, chief executive of  Causeway Sensors, a spin-off company from Queen’s University Belfast  set up by   Pollard –  along with  Robert Bowman and John Nelson –  which has developed nano-sized sensing chips   used to detect early-stage cancer

Belfast-based Causeway Sensors makes nano-sized chips used to detect diseases

When can I have one? The help-to-buy rebate scheme applies to homes bought since July 19th, 2016, but Revenue will not start processing applications until January 1st, 2017. Photograph: Brian Lawless/PA Wire

Mortgage relief of up to €20,000 will be available to owner occupiers in new builds

“There is nothing to stop either or both parents gifting up to €3,000 to each child in any calendar year.” Photograph: Alan Betson/The Irish Times

Q&A: Dominic Coyle answers your personal finance questions

The Government has signalled that it intends to increase the threshold on the amount a child may inherit or receive as gifts over their lifetime from parents.

Affluent parents have used loosely worded law to tax-efficiently provide for children

A glitch in rules introduced in 2014 has put people whose income comes from “unearned” sources  at risk of losing access to the State pension. Photograph: Willie B Thomas

Leo Varadkar urged to seek amendment of ‘grossly unfair’ rules on ‘unearned’ income

Venn Life Sciences’ Labskin: Clinical trials group owns 70 per cent of Innovenn following the conversion of a £1.3 million loan into equity ahead of the sale

Clinical trials group selling technology development subsidiary to UK firm Integumen

Mortgage debt is, for most of us, the cheapest money we will ever borrow. Photograph: Rui Vieira/PA Wire

Q&A: Dominic Coyle

John McGrath: “In this business, proven technology stands for a lot. You don’t want to be on the bleeding edge.”

Irishman John McGrath is responsible for GSK’s global vaccine manufacturing

Venn Life Sciences has put its Innovenn division, which has been working on developing synthetic skin products for use in clinical trials, on the market

Investment in synthetic skin project that is being sold widens operating loss

Cúram centre in NUIG: Research approach is designed to facilitate a move from basic research to clinical application as efficiently and quickly as possible.  Photograph: Andrew Downes/xposure

Cúram facility in NUI Galway brings universities and industry together to fight disease

A recent Aviva study on pensions found that, on average, workers needed to put an additional €1,000 a month into their pension savings. Photograph: Getty Images

Report shows 80% happy to be automatically enrolled in a pension when taking up a job

If you have been banking with AIB since the Visa card episode, and have had a clean banking “record” over the past decade, then the issue is of slightly more concern. Photograph: Cyril Byrne

Q&A: Dominic Coyle answers your personal finance questions

Minister for Jobs, Enterprise and Innovation Mary Mitchell O’Connor, Legacy Lifestyles chief executive David Edwards and Oneview Healthcare president  Mark McCloskey.

Half of the new staff to be based in Dublin

A married daughter-in-law is just as much a “stranger” under the gift tax code – formally the capital acquisitions tax – as a blood relative’s unmarried partner

Q&A: Dominic Coyle answers your financial queries

Tax returns: Revenue will not automatically assume that suspended shares have no value

Q&A: Dominic Coyle answers your financial queries

Fountain Healthcare Partners managing director Dr Manus Rogan with Inflazome chief executive Prof Matt Cooper, co-founder Prof Luke O’Neill and business development vice-president Dr Jeremy Skillington. Photograph: Nick Bradshaw

Inflazome has drug ready to enter human clinical trials

There is concern that the “dwelling-house exemption” is being abused by wealthy individuals to effectively buy plush homes for their children. Photograph: Cyril Byrne

The law has a ‘dwelling-house exemption’ that allows parents ‘gift’ a home to a child

Tall order: Aviva recommends putting €12,200 a year into your pension. Photograph: Ivan Bliznet/iStock

A new report is the latest to warn we’re not saving nearly enough for retirement

Only a fraction of the 40 per cent of smokers who try to quit each year succeed, says Liz Rockett of Kaiser Permanente Ventures, which is investing in Chrono Therapeutics’ stop smoking technology, along with Ireland’s Fountain Healthcare Partners.  Photograph: Bryan O’Brien

Chrono Therapeutics developing device to deliver nicotine through skin in timed doses

Galway med-tech start-up Vivasure Medical’s PerQseal technology allows surgeons to close large holes in major arteries after surgery without having to open patients up.

Start-up’s technology allows surgeons to finish heart surgery without leaving stitches

A study by insurer Aviva says, on average, Irish people need to increase the amount they save by more than €1,000 a month

Shortfall widens between savings and amount needed for 'adequate' retirement income

You can rebuild a credit rating in the same way as you can damage one – though your track record on repayments.

Q&A: Dominic Coyle answers your questions

Derek Young, founder and chief executive of i360 Medical: The company started life as the Centre for Innovation in Surgical Technology at the Royal College of Surgeons in Ireland in 2009. Photograph: Dara Mac Dónaill

Derek Young’s i360 is a one-stop shop for outsourced healthcare engineering R&D

Those born on or after January 1st, 1961  will not get the State pension until they are 68

Increasing retirement age attempts to address imbalance between workers and pensioners

Minister for Public Expenditure and Reform Paschal Donohoe noted changes to public service employment rules in 2013 mean recently recruited staff can avail of a maximum retirement age of 70. Photograph: Gareth Chaney Collins

Donohoe will call on private sector to allow employees participate in workforce longer

Those born on or after January 1st, 1961  will not get the State pension until they are 68

Those born before 1955 can retire at 66, others will have to wait until they are older

 Bruce Cozadd, chief executive of Jazz Pharmaceuticals, the speciality drug business that has just opened a new facility in Athlone. Photograph: Dara Mac Dónaill/The Irish Times

Speciality drug business blames recent acquisition and guidance from SEC

Mercer, which tracks the pension position of Ireland’s largest listed companies – members of the Iseq 20 – says the gap has widened dramatically this year. Photograph: Getty Images

Investments floundering due to volatile markets and ECB stimulus scheme

Bank of Ireland is looking into its history with tracker customers.

Documentation is crucial to any potential claim for compensation

Company targets expanded market share for fish oil drug that cuts risk of heart disease

 Bruce Cozadd, chief executive of Jazz Pharmaceuticals: ‘The remarkable pro-business environment in Ireland facilitates investments like this one.’ Photograph: Dara Mac Dónaill / The Irish Times

Nasdaq-listed specialty drug group expects to create 50 new jobs over three years

A reader says Permanent TSB told him he could open a sterling account only for deposits. Photograph: Alan Betson

Not all Irish banks are the same in relation to opening sterling accounts

Alcon Laboratories Ireland said the company’s 2015 performance was “strong” due to increased demand for its lenses. Photograph: Alastair Miller/Bloomberg

Project expenditure contributes to 4 per cent profit decline at Cork-based eye lens business

The most significant business during the first quarter of this year was the purchase of a 10 per cent stake in Ion Trading by Carlyle Partners for about €359 million.

Deals with aggregate value of €1.283 billion finalised in second quarter, says survey

Results filed with Companies House show Ardmore Studios had earnings of €1.35 million in 2015. Photograph: Alan Betson

Company reports year-end profit of €865,000 after strong demand for studio space

The headquarters of clinical trials group Icon at Leopardstown in Dublin.

Irish group boosts business after takeover of US rival ClinicalRM

The annual notional rent – minus the €3,000 small gift exemption that you are allowed give to your son or anyone else – will be treated as a gift under the capital acquisition tax/gift tax rules

Dominic Coyle answers your personal finance questions

Minister for Finance Michael Noonan: “For insured motorists, this will facilitate speedier payments and a simplification of the claims procedure.” Photograph: Julien Warnand/EPA

Insurance Ireland says plan to make insurers pay 35% of third-party motor claims is ‘flawed’

Minister for Health Simon Harris: “We had seen our drugs bill spiralling somewhat out of control.”  Photograph: Brenda Fitzsimons

Agreement should help bring prices down to European average, says Simon Harris

Minister for Health Simon Harris at the beginning of construction of the new children’s hospital at St James’s Hospital, Dublin. Photograph: Brenda Fitzsimons/The Irish Times

Minister for Health says he would rather clinicians made decisions not politicians

The introduction of annual pricing reviews – rather than the price being locked in at the start of a four-year deal –  after which prices can only fall, makes sense. File photograph: PA Wire

The Government can expect savings on healthcare and ‘Big Pharma’ now has clarity

Pfizer plans to build a five-storey biopharma manufacturing unit in two phases, adding more than 34,500sq m to its current footprint on what is already one of the largest biotechnology plants in the world. Photograph:   Andrew Kelly/Reuters

US pharma giant expects to invest up to €400 million in west Dublin biopharma plant

  Telecom Éireann share   price allocation: Most of the donations to Sharegift were made by investors who lost money in the long run over the 1999 flotation and found themselves holding Vodafone shares. Photograph: Eric Luke

Small scale Telecom Éireann investors donate through Sharegift system

An Ebola burial site in  Sierra Leone. Concern Worldwide  and the International Federation of the Red Cross took over the safe burial of victims in a way which allowed family members to be present. They had previously been barred amid fears of contagion.  Photograph: Concern Worldwide

Emergency response appeals in South Sudan, Sierra Leone, Liberia and Nepal saw spending jump 29% to new high

The HEA has written to Minister for Health Simon Harris expressing its concern over what it calls the “biosimilar blocker”. Photograph: Dave Meehan

Providers of branded patent drugs and generics face off over provison in draft agreement on drug prices

 Minister for Health Simon Harris:  in the letter sent to him the Healthcare Enterprise Alliance says the pricing agreement includes “artificial pricing thresholds”. Photograph: Dave Meehan

Generics lobby warns Government new deal with Big Pharma will stifle competition

The Grange Castle plant produces some of Pfizer’s biggest drugs, including the arthritis blockbuster Enbrel and the vaccine Prevenar,  used in children to prevent pneumococcal infections. Photograph: Dara Mac Dónaill

Several hundred jobs likely to be created at former Wyeth facility in west Dublin

The average Irish shareholder had about 675 shares in Standard Life following its flotation and the subsequent issue of loyalty shares.

Thousands of Irish people entitled to windfall could lose out for good

Innocoll expects to raise about $40 million in the flotation. Photograph: Alan Betson

Firm developing products to treat postoperative pain and diabetic foot infections

Mainstay Medical chief executive Peter Crosby said the fundraising would allow the business to progress its plans to commercialise the business in Europe and the United States “and help improve the lives of millions of people who suffer from chronic low back pain”. (Photograph: Nick Bradshaw)

Irish company has won European approval of neurostimulator to treat chronic lower back pain and targeting US market

Dublin: while the corporation tax rate was just one of a number of factors, the current low rate was seen as critical for Ireland, says an ESRI study. Photograph: iStock

Changes hit Ireland harder than its European partners when securing US investment

Amryt is now focused on clinical trials on a potential therapy for a rare skin disorder called epidermolysis bullosa

Orphan drug development business was subject to reverse takeover by oil and gas group Fastnet

Vodafone has 334,342 shareholders in Ireland holding fewer that 1,000 each - compared to just 66,500 in the UK. Of the Irish shareholders 103,300 hold fewer than 50 shares.

Shares were trading in London on Friday at just over €2.96

While banks are scrupulous in letting you know that the rate on your loan has gone down (or up),  I cannot recall ever getting a letter saying you can get an even lower rate by switching to another, newer, product in the bank’s portfolio.

Plus: Can I still sell Verizon shares at special low cost?

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